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This study was undertaken to synthesize some novel nitroaryl\/heteroaryl hydrazone derivatives as potential antibacterial agents. After synthesizing by a simple reaction between quinoline\/quinazoline hydrazine and nitroaryl\/heteroaryl aldehydes, all the compounds were screened for their antibacterial activities, cytotoxicity and in silico investigations. The compound, 2-(4-nitrobenzylidene)-1-(quinazolin-4-yl)hydrazine (1b), displayed significant antimicrobial activity against several susceptible and resistant bacteria without any cytotoxicity. Moreover, scanning electron microscopy (SEM) revealed the complete destruction of Staphylococcus aureus and Escherichia coli following exposure to this compound after 2 h exposure. The in silico studies confirmed the better binding energy of these compounds in comparison with the reference drugs in complex with topoisomerase IV and bacterial ribosomal receptor. Compound 1b can be considered a promising lead compound for the development of broad-spectrum antibacterial medications after further studies.<\/jats:p>","DOI":"10.1111\/lam.13692","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T20:34:35Z","timestamp":1648240475000},"page":"667-679","source":"Crossref","is-referenced-by-count":11,"title":["Hydrazone analogues with promising antibacterial profiles: Synthesis, morphology, in vitro and in silico approaches"],"prefix":"10.1093","volume":"75","author":[{"given":"M.","family":"Nabizadeh","sequence":"first","affiliation":[{"name":"Research Laboratory of Green Organic Synthesis and Polymers Department of Chemistry Iran University of Science and Technology Tehran Iran"},{"name":"Medicinal Chemistry Laboratory Department of Clinical Research Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.R.","family":"Naimi-Jamal","sequence":"additional","affiliation":[{"name":"Research Laboratory of Green Organic Synthesis and Polymers Department of Chemistry Iran University of Science and Technology Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rohani","sequence":"additional","affiliation":[{"name":"Department of Microbiology Pasteur Institute of Iran Tehran Iran"},{"name":"Research Center for Emerging and Reemerging Infectious Diseases Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Azerang","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Laboratory Department of Clinical Research Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1221-4490","authenticated-orcid":false,"given":"A.","family":"Tahghighi","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Laboratory Department of Clinical Research Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"2023011712241853000_lam13692-bib-0001","doi-asserted-by":"crossref","first-page":"128301","DOI":"10.1016\/j.molstruc.2020.128301","article-title":"Development of colorimetric cotton swab using molecular switching hydrazone probe in calcium alginate","volume":"1216","author":"Abdelrahman","year":"2020","journal-title":"J Mol Struct"},{"key":"2023011712241853000_lam13692-bib-0002","first-page":"836","article-title":"Antibacterial Chitosan of Milkfish Scales (Chanos chanos) on Bacteria Prophyromonas gingivalis & Agregatibacter actinomycetemcomitans","volume":"11","author":"Achmad","year":"2020","journal-title":"Syst Rev Pharm"},{"key":"2023011712241853000_lam13692-bib-0003","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/jhet.3050","article-title":"Microwave assisted synthesis and antimicrobial potential of quinoline-based 4-hydrazide-hydrazone Derivatives","volume":"55","author":"Ajani","year":"2018","journal-title":"J Heterocycl Chem"},{"key":"2023011712241853000_lam13692-bib-0004","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.2174\/1389557520999201209213648","article-title":"Imidazole derivatives and their antibacterial activity \u2013 a mini-review","volume":"21","author":"Andrei","year":"2021","journal-title":"Mini Rev Med Chem"},{"key":"2023011712241853000_lam13692-bib-0005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpha.2015.11.005","article-title":"Methods for in vitro evaluating antimicrobial activity: a review","volume":"6","author":"Balouiri","year":"2016","journal-title":"J Pharm Anal"},{"key":"2023011712241853000_lam13692-bib-0006","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1472-765X.2012.03234.x","article-title":"In vitro antimalarial activity and molecular docking analysis of 4-aminoquinoline-clubbed 1,3,5-triazine derivatives","volume":"54","author":"Bhat","year":"2012","journal-title":"Lett Appl Microbiol"},{"key":"2023011712241853000_lam13692-bib-0007","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12866-017-1033-3","article-title":"Identification of Enterococcus faecalis enzymes with azoreductases and\/or nitroreductase activity","volume":"17","author":"Chalansonnet","year":"2017","journal-title":"BMC Microbiol"},{"key":"2023011712241853000_lam13692-bib-0008","volume-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically: M07\u2013A10; 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