{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:07:50Z","timestamp":1783508870287,"version":"3.55.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study evaluated antibiotic susceptibility and presence of blaOXA22 and blaOXA60 genes in 81 isolates of Ralstonia pickettii obtained from different purified and ultra-pure water systems in two different geographical areas of Croatia. E-test and disc diffusion test were performed to determine antibiotic susceptibility. Polymerase chain reaction was applied to detect genes encoding OXA-22 and OXA-60 oxacillinases previously identified in R. pickettii. The isolates were genotyped by pulsed-field gel electrophoresis. The results revealed variable susceptibility\/resistance profiles. Our isolates exhibited high susceptibility rates to ceftriaxone, cefotaxime, piperacillin-tazobactam, ciprofloxacin, imipenem, cefepime and in lesser extent to ceftazidime. High rates of susceptibility were also observed for sulphamethoxazole-trimethoprim and piperacillin. High resistance rates were noticed for ticarcillin-clavulanate, aztreonam and meropenem, as well as for all aminoglycosides tested. Modified Hodge test was positive in 51\u00b79% strains, indicating production of carbapenemases. blaOXA22 and blaOXA60 genes were detected in 37\u00b70 and 80\u00b73% strains, respectively. Pulsed-field gel electrophoresis identified three major clusters containing subclusters. R. pickettii should be taken seriously as a possible cause of nosocomial infections to ensure adequate therapy, to prevent the development of resistant strains and to try to reduce the possibility of R. pickettii surviving in clean and ultra clean water systems.<\/jats:p>","DOI":"10.1111\/lam.13711","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T07:51:48Z","timestamp":1648626708000},"page":"103-113","source":"Crossref","is-referenced-by-count":8,"title":["Oxacillinases and antimicrobial susceptibility of Ralstonia pickettii from pharmaceutical water systems in Croatia"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1775-0807","authenticated-orcid":false,"given":"I.","family":"Batarilo","sequence":"first","affiliation":[{"name":"Croatian Institute for Transfusion Medicine Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Maravic-Vlahovicek","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Biochemistry University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bedenic","sequence":"additional","affiliation":[{"name":"School of Medicine University of Zagreb Zagreb Croatia"},{"name":"University Hospital Center Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kazazic","sequence":"additional","affiliation":[{"name":"Ru\u0111er Bo\u0161kovi\u0107 Institute Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bingulac-Popovic","sequence":"additional","affiliation":[{"name":"Croatian Institute for Transfusion Medicine Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Slade-Vitkovic","sequence":"additional","affiliation":[{"name":"Croatian Institute for Transfusion Medicine Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kati\u0107","sequence":"additional","affiliation":[{"name":"University Hospital Center Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Jukic","sequence":"additional","affiliation":[{"name":"Croatian Institute for Transfusion Medicine Zagreb Croatia"},{"name":"Josip Juraj Strossmayer University of Osijek Osijek Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"2023011712243164800_lam13711-bib-0001","first-page":"151","volume-title":"Biofilms Persistence and 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