{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:32:08Z","timestamp":1771864328866,"version":"3.50.1"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"crossref","award":["DGAPA-PAPIIT - IG200821"],"award-info":[{"award-number":["DGAPA-PAPIIT - IG200821"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Instituto de Investigaciones en Ecosistemas y Sustentabilidad, UNAM","award":["PO-FJEG"],"award-info":[{"award-number":["PO-FJEG"]}]},{"name":"F.J. Espinosa-Garc\u00eda Personal Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We evaluated an essential oil (EO) of Tagetes lucida Cav. and the mixture of its main compounds against multi-drug resistant bacteria. We found that EO and the partially reconstituted blend of its main components have antibacterial activity and inhibit antibiotic resistance (ampicillin, chloramphenicol, nalidixic acid, vancomycin and imipenem) in strains of Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa HIM-MR01. The T. lucida EO alone or added to the antibiotics showed antimicrobial activity against S. aureus and P. aeruginosa. The EO main bioactive compounds were methyl eugenol (relative abundance in EO: 46\u00b715%), estragole (32\u00b793%), linalool (2\u00b748%) and geraniol (0\u00b733%). The mixture (PREO) of those compounds at those proportions inhibited the growth of P. aeruginosa in 45% at 683\u00b762 \u00b5g ml\u22121 and that of S. aureus in 51\u00b77% at 39\u00b704 \u00b5g ml\u22121. The PREO had higher antibacterial and modulatory activities than the original EO. In conclusion, we overcame the unpredictability of EO activity (due to their natural variability) by determining which EO components inhibited bacteria and then producing a PREO to generate a reproducible mixture with predictable antibacterial and modulation of resistance activities. Thus, the PREO, and its components, show potential as alternatives to manage multidrug-resistant pathogens.<\/jats:p>","DOI":"10.1111\/lam.13721","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T07:43:19Z","timestamp":1649922199000},"page":"210-223","source":"Crossref","is-referenced-by-count":11,"title":["Tagetes lucida Cav. essential oil and the mixture of its main compounds are antibacterial and modulate antibiotic resistance in multi-resistant pathogenic bacteria"],"prefix":"10.1093","volume":"75","author":[{"given":"R.","family":"Torres-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Laboratorio de Ecolog\u00eda Qu\u00edmica y Agroecolog\u00eda Instituto de Investigaciones en Ecosistemas Universidad Nacional Aut\u00f3noma de M\u00e9xico Morelia M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Moreno-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio de Ecolog\u00eda Qu\u00edmica y Agroecolog\u00eda Instituto de Investigaciones en Ecosistemas Universidad Nacional Aut\u00f3noma de M\u00e9xico Morelia M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.M.","family":"Garc\u00eda-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Ecolog\u00eda Qu\u00edmica y Agroecolog\u00eda Instituto de Investigaciones en Ecosistemas Universidad Nacional Aut\u00f3noma de M\u00e9xico Morelia M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hern\u00e1ndez-Delgado","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioactividad de Productos Naturales UBIPRO FES-Iztacala Universidad Nacional Aut\u00f3noma de M\u00e9xico Tlalnepantla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Delgado-Lamas","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico Circuito Exterior Ciudad Universitaria Coyoac\u00e1n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9173-1957","authenticated-orcid":false,"given":"F.J.","family":"Espinosa-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Ecolog\u00eda Qu\u00edmica y Agroecolog\u00eda Instituto de Investigaciones en Ecosistemas Universidad Nacional Aut\u00f3noma de M\u00e9xico Morelia M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"2023011712241644500_lam13721-bib-0001","first-page":"671","volume-title":"Identification of Essential Oil Components by Gas Chromatography\/ Mass Spectrometry","author":"Adams","year":"2007","edition":"4th ed"},{"key":"2023011712241644500_lam13721-bib-0002","first-page":"115","article-title":"Antibacterial activity of lavender essential oil and linalool combined with gentamicin on 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