{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:01:22Z","timestamp":1790136082627,"version":"4.0.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009055","name":"Canakkale Onsekiz Mart University","doi-asserted-by":"crossref","award":["FDK 2021 3454"],"award-info":[{"award-number":["FDK 2021 3454"]}],"id":[{"id":"10.13039\/100009055","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The detection of resistant strains of Clostridioides difficile against existing antibiotics and the side effects led to the investigation of alternative agents. Inhibition zones of various essential oils to four strains of C.difficile and other Clostridium species ranged from 8\u00b732 to 44\u00b718 mm. The highest zone was observed in cinnamon and tea tree essential oils. and The MIC values varied between 0\u00b739\u201325 (%, v\/v). The main components were cinnamaldehyde (85\u00b764%) in cinnamon essential oil, 4-terpineol (83\u00b76%) was determined in tea tree essential oil. Additive effects were found between cinnamon essential oil and vancomycin and between cinnamon and tea tree essential oils, and the FICI values were 0\u00b7512 and 0\u00b7517, respectively. Both cinnamon and tea tree essential oils showed antibiofilm activities against all tested C. difficile strains at all tested concentrations. Essential oils may be used as a supplement in addition to treatment in the control of C. difficile-related diseases.<\/jats:p>","DOI":"10.1111\/lam.13747","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T07:25:05Z","timestamp":1653463505000},"page":"598-606","source":"Crossref","is-referenced-by-count":11,"title":["Antibacterial and antibiofilm activities of some plant essential oils and synergistic effects of cinnamon essential oil with vancomycin against Clostridioides difficile: in vitro study"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6451-7354","authenticated-orcid":false,"given":"M.N.","family":"Tosun","sequence":"first","affiliation":[{"name":"Canakkale Onsekiz Mart University Engineering Faculty Food Engineering Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2146-8254","authenticated-orcid":false,"given":"G.","family":"Taylan","sequence":"additional","affiliation":[{"name":"Canakkale Onsekiz Mart University Engineering Faculty Food Engineering Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6851-6474","authenticated-orcid":false,"given":"N.N.","family":"Demirel Zorba","sequence":"additional","affiliation":[{"name":"Canakkale Onsekiz Mart University Engineering Faculty Food Engineering Canakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"2023011712242276400_lam13747-bib-0001","first-page":"50","article-title":"Conventional and alternative treatment approaches for Clostridium difficile infection","volume":"11","author":"Aljarallah","year":"2017","journal-title":"Int J Health Sci"},{"key":"2023011712242276400_lam13747-bib-0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-61604-z","article-title":"High prevalence of Clostridiodes difficile PCR ribotypes 001 and 126 in Iran","volume":"10","author":"Baghani","year":"2020","journal-title":"Sci Rep"},{"key":"2023011712242276400_lam13747-bib-0003","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3390\/antibiotics4030267","article-title":"Antimicrobial resistance and reduced susceptibility in Clostridium difficile: potential consequences for induction, treatment, and recurrence of C. difficile infection","volume":"4","author":"Baines","year":"2015","journal-title":"Antibiotics"},{"key":"2023011712242276400_lam13747-bib-0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/8414257","article-title":"Clostridium difficile \u0131nfections: a global overview of drug sensitivity and resistance mechanisms","volume":"2018","author":"Banawas","year":"2018","journal-title":"Biomed Res Int"},{"key":"2023011712242276400_lam13747-bib-0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/5190603","article-title":"Chemical composition and antioxidant, antimicrobial, and antiproliferative activities of cinnamomum zeylanicum bark essential oil","volume":"2020","author":"Behbahani","year":"2020","journal-title":"Evid-based Complement Altern Med"},{"key":"2023011712242276400_lam13747-bib-0006","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/infdis\/137.2.122","article-title":"A method for testing for synergy with any number of agents","volume":"137","author":"Berenbaum","year":"1978","journal-title":"J Infect Dis"},{"key":"2023011712242276400_lam13747-bib-0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/f12050648","article-title":"The potential role of cinnamon in human health","volume":"12","author":"B\u0142aszczyk","year":"2021","journal-title":"Forests"},{"key":"2023011712242276400_lam13747-bib-0008","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/CMR.19.1.50-62.2006","article-title":"Melaleuca alternifolia (tea tree) oil: a review of antimicrobial and other medicinal properties","volume":"19","author":"Carson","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"2023011712242276400_lam13747-bib-0009","volume-title":"Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria. 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