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Furthermore, the relentless emergence of multidrug-resistant bacteria, particularly in the biofilm state, has made mandatory the discovery of new alternative antimicrobial therapies that are capable to eradicate resistant bacteria and impair the development of new forms of resistance. Amongst the therapeutic strategies for treating biofilms, antimicrobial photodynamic therapy (aPDT) has shown great potential in inactivating several clinically relevant micro-organisms, including antibiotic-resistant \u2018priority bacteria\u2019 declared by the WHO as critical pathogens. Its antimicrobial effect is centred on the basis that harmless low-intensity light stimulates a non-toxic dye named photosensitizer, triggering the production of reactive oxygen species upon photostimulation. In addition, combination therapies of aPDT with other antimicrobial agents (e.g. antibiotics) have also drawn considerable attention, as it is a multi-target strategy. Therefore, the present review highlights the recent advances of aPDT against biofilms, also covering progress on combination therapy.<\/jats:p>","DOI":"10.1111\/lam.13762","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T06:55:07Z","timestamp":1654930507000},"page":"548-564","source":"Crossref","is-referenced-by-count":51,"title":["Photodynamic therapy and combinatory treatments for the control of biofilm-associated infections"],"prefix":"10.1093","volume":"75","author":[{"given":"M.","family":"Ribeiro","sequence":"first","affiliation":[{"name":"LEPABE \u2013 Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering University of Porto Porto Portugal"},{"name":"ALiCE \u2013 Associate Laboratory in Chemical Engineering, Faculty of Engineering University of Porto Porto Portugal"},{"name":"CIQUP\/Department of Chemistry and Biochemistry, Faculty of Sciences University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.B.","family":"Gomes","sequence":"additional","affiliation":[{"name":"LEPABE \u2013 Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering University of Porto Porto Portugal"},{"name":"ALiCE \u2013 Associate Laboratory in Chemical Engineering, Faculty of Engineering University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, School of Agriculture and Veterinary Science UTAD Vila Real Portugal"},{"name":"Centre for the Research and Technology for Agro-Environment and Biological Sciences (CITAB) UTAD Vila Real 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