{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:34:41Z","timestamp":1788374081807,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Staphylococcus aureus is one of the main aetiological agents causing food-borne diseases. Some strains produce enterotoxins responsible for food poisoning. In addition, they can form biofilms on several surfaces such as plastics, glass and stainless steel making it difficult to eliminate them. The present study evaluated, for the first time, the antibacterial and antibiofilm activities of the synthetic compound LMM6 against S. aureus. The minimum inhibitory concentration was 0\u00b797, 1\u00b795 and 1\u00b795 \u03bcg ml\u22121 against S. aureus ATCC 25923, S. aureus 629\/94 and S. aureus FRI S-6, respectively. The time-kill curves showed that 96 h treatment with LMM6 reduced approximately 4 log CFU per ml at all tested concentrations. Furthermore, LMM6 reduced S. aureus preformed biofilm by approximately 1 log CFU per cm2. During biofilm formation, a reduction of approximately 4 log CFU per cm2 was observed. LMM6 also reduced biofilm biomass during (~60%) and after biofilm formation (~25 to 45%), as shown by the crystal violet assay. Based on these results, we conclude that LMM6 exhibits antibacterial and antibiofilm activity and may be an innovative synthetic molecule for controlling S. aureus.<\/jats:p>","DOI":"10.1111\/lam.13766","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T12:21:25Z","timestamp":1655209285000},"page":"957-966","source":"Crossref","is-referenced-by-count":6,"title":["New 1,3,4-oxadiazole compound with effective antibacterial and antibiofilm activity against Staphylococcus aureus"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0616-3305","authenticated-orcid":false,"given":"M.","family":"Dante Formagio","sequence":"first","affiliation":[{"name":"Postgraduate Program of Health Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.V.","family":"de Oliveira Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Health Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Fortunato Prohmann","sequence":"additional","affiliation":[{"name":"State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.","family":"Zanetti Campanerut-S\u00e1","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Health Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"},{"name":"Department of Clinical Analysis and Biomedicine State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.R.","family":"Grenier Capoci","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9.","family":"Seki Kioshima Cotica","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Graton Mikcha","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Health Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"},{"name":"Department of Clinical Analysis and Biomedicine State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,1]]},"reference":[{"key":"2023011712235728700_lam13766-bib-0001","volume-title":"Pecu\u00e1ria e Abastecimento, Instru\u00e7\u00e3o Normativa N\u00b0 30 de 26\/06\/2018","author":"BRASIL. 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