{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:03:15Z","timestamp":1762254195048,"version":"3.37.3"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Natural Science Foundation of Huzhou Science and Technology","award":["2021YZ23"],"award-info":[{"award-number":["2021YZ23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Human adenoviruses (HAdVs) are prevalent worldwide and are a common cause of respiratory tract infection in people of all ages. However, little is known about HAdV infection among children with severe acute respiratory infection (SARI). The present study retrospectively analysed the molecular typing and epidemiological characteristics of HAdV-positive samples from children with SARI from January 2017 to December 2021 in Huzhou. The results showed that 89 (8\u00b727%) of 1078 SARI paediatric patients were positive for HAdVs. Children &amp;lt;5 years of age accounted for 87\u00b764% of the positive cases. The peak seasons for HAdV infection were the first quarter and the fourth quarter. In addition, HAdV-B and HAdV-C were circulating among paediatric patients with SARI, of which the B3 genotype (n = 30, 51\u00b772%) was the most prevalent and was detected every year, indicating that B3 is the main epidemic strain in the Huzhou area, followed by C1 (n = 9, 15\u00b752%), C2 (n = 7, 12\u00b707%) and B7 (n = 5, 8\u00b762%). These findings provide a benchmark for future epidemiology and prevention strategies for HAdVs.<\/jats:p>","DOI":"10.1111\/lam.13790","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T14:39:12Z","timestamp":1658414352000},"page":"1225-1231","source":"Crossref","is-referenced-by-count":2,"title":["Molecular typing and epidemiology profiles of human adenovirus infection among children with severe acute respiratory infection in Huzhou, China"],"prefix":"10.1093","volume":"75","author":[{"given":"D.","family":"Xu","sequence":"first","affiliation":[{"name":"Huzhou Center for Disease Control and Prevention Huzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ji","sequence":"additional","affiliation":[{"name":"Huzhou Center for Disease Control and Prevention Huzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1753-7245","authenticated-orcid":false,"given":"L.","family":"Chen","sequence":"additional","affiliation":[{"name":"Huzhou Center for Disease Control and Prevention Huzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Wu","sequence":"additional","affiliation":[{"name":"Huzhou Center for Disease Control and Prevention Huzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"2023011712231377500_lam13790-bib-0001","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1743-422X-10-15","article-title":"Temporal changes in respiratory adenovirus serotypes circulating in the greater Toronto area, Ontario, during December 2008 to April 2010","volume":"10","author":"Abbas","year":"2013","journal-title":"Virol J"},{"key":"2023011712231377500_lam13790-bib-0002","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jcv.2011.11.001","article-title":"Molecular typing of adenoviruses in pediatric respiratory infections in Buenos Aires, Argentina (1999\u20132010)","volume":"53","author":"Barrero","year":"2012","journal-title":"J Clin Virol"},{"key":"2023011712231377500_lam13790-bib-0003","article-title":"Genetic variability of human adenovirus type 7 circulating in mainland China","volume":"15","author":"Cai","year":"2020","journal-title":"PLoS One"},{"key":"2023011712231377500_lam13790-bib-0004","article-title":"Viral co-infections in pediatric patients hospitalized with lower tract acute respiratory infections","volume":"10","author":"Cebey","year":"2015","journal-title":"PLoS One"},{"key":"2023011712231377500_lam13790-bib-0005","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1099\/vir.0.19497-0","article-title":"Genetic content and evolution of adenoviruses","volume":"84","author":"Davison","year":"2003","journal-title":"J Gen Virol"},{"key":"2023011712231377500_lam13790-bib-0006","article-title":"Genetic diversity of human adenovirus in children with acute gastroenteritis, Albania, 2013\u20132015","volume":"2015","author":"Della","year":"2015","journal-title":"Biomed Res Int"},{"key":"2023011712231377500_lam13790-bib-0007","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/s41598-018-37249-4","article-title":"Molecular evolution of human adenovirus (HAdV) species C","volume":"9","author":"Dhingra","year":"2019","journal-title":"Sci Rep"},{"key":"2023011712231377500_lam13790-bib-0008","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152375","article-title":"Epidemiology and clinical characteristics of respiratory infections due to adenovirus in children living in Milan, Italy, during 2013 and 2014","volume":"11","author":"Esposito","year":"2016","journal-title":"PLoS One"},{"key":"2023011712231377500_lam13790-bib-0009","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1097\/INF.0b013e3182145277","article-title":"The burden of rotavirus disease in Denmark 2009\u20132010","volume":"30","author":"Fischer","year":"2011","journal-title":"Pediatr Infect DisJ"},{"key":"2023011712231377500_lam13790-bib-0010","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jinf.2014.06.015","article-title":"A human adenovirus species B subtype 21a associated with severe pneumonia","volume":"69","author":"Hage","year":"2014","journal-title":"J Infect"},{"key":"2023011712231377500_lam13790-bib-0011","first-page":"114","article-title":"Clinical characteristics and prevalence of adenovirus with respiratory tract infections in children","volume":"27","author":"Lin","year":"2020","journal-title":"Chinese Pediatr Emerg Med"},{"key":"2023011712231377500_lam13790-bib-0012","first-page":"711","article-title":"Characteristics and genotyping of 182 preschool children with acute respiratory adenovirus infection in southeast minority areas of Chongqing","volume":"25","author":"Huang","year":"2020","journal-title":"J Clin Pulm Med"},{"key":"2023011712231377500_lam13790-bib-0013","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/CMR.00116-13","article-title":"Adenovirus infections in immunocompetent and immunocompromised patients","volume":"27","author":"Lion","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"2023011712231377500_lam13790-bib-0014","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1186\/s12879-015-1126-2","article-title":"Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007\u20132012","volume":"15","author":"Liu","year":"2015","journal-title":"BMC Infect Dis"},{"key":"2023011712231377500_lam13790-bib-0015","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00705-005-0722-7","article-title":"Molecular typing of human adenoviruses by PCR and sequencing of a partial region of the hexon gene","volume":"151","author":"Lu","year":"2006","journal-title":"Arch Virol"},{"key":"2023011712231377500_lam13790-bib-0016","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1080\/14760584.2019.1588113","article-title":"A review of 65 years of human adenovirus seroprevalence","volume":"18","author":"Mennechet","year":"2019","journal-title":"Expert Rev Vaccines"},{"volume-title":"Circular of the General Office of the Ministry of Health on the issuance of the sentinel surveillance programme (2011 edition) for hospitalized cases of severe acute respiratory infections (EB\/OL) (2011-02-11) [2014-11-17]","year":"2011","author":"Ministry of Health of the People's Republic of China","key":"2023011712231377500_lam13790-bib-0017"},{"key":"2023011712231377500_lam13790-bib-0018","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofy188","article-title":"Adenovirus type 21 outbreak among lung transplant patients at a large tertiary care hospital","volume":"5","author":"Philo","year":"2018","journal-title":"Open Forum Infect Dis"},{"key":"2023011712231377500_lam13790-bib-0019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147041","article-title":"Etiology of acute respiratory tract infections in hospitalised children in Cyprus","volume":"11","author":"Richter","year":"2016","journal-title":"PLoS One"},{"key":"2023011712231377500_lam13790-bib-0020","first-page":"3658","article-title":"Molecular epidemiological characteristics of children with acute respiratory adenovirus infection in Leshan from 2016 to 2020","volume":"31","author":"Rao","year":"2021","journal-title":"Chinese J Nosocomiol"},{"key":"2023011712231377500_lam13790-bib-0021","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jcv.2016.03.002","article-title":"Outbreak of adenovirus type 55 infection in Israel","volume":"78","author":"Salama","year":"2016","journal-title":"J Clin Virol"},{"key":"2023011712231377500_lam13790-bib-0022","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1186\/s13054-014-0456-6","article-title":"Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study","volume":"18","author":"Sun","year":"2014","journal-title":"Crit Care"},{"key":"2023011712231377500_lam13790-bib-0023","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/INF.0b013e318256605e","article-title":"Adenovirus respiratory infections in hospitalized children: clinical findings in relation to species and serotypes","volume":"31","author":"Tabain","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"2023011712231377500_lam13790-bib-0024","first-page":"2057","article-title":"Genotyping of respiratory adenovirus infections in Hefei City, 2019","volume":"31","author":"Tang","year":"2021","journal-title":"Chinese J Health Lab Technol"},{"key":"2023011712231377500_lam13790-bib-0025","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12985-019-1185-x","article-title":"Human adenovirus among hospitalized children with respiratory tract infections in Beijing, China, 2017\u20132018","volume":"16","author":"Yao","year":"2019","journal-title":"Virol J"},{"key":"2023011712231377500_lam13790-bib-0026","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/1348-0421.12074","article-title":"Outbreak of acute respiratory disease caused by human adenovirus type 7 in a military training camp in Shaanxi, China","volume":"57","author":"Yu","year":"2013","journal-title":"Microbiol Immunol"},{"key":"2023011712231377500_lam13790-bib-0027","first-page":"772","article-title":"Epidemiological characteristics of adenovirus infection in hospitalized children with acute respiratory tract infection in Kunming during 2019","volume":"59","author":"Yue","year":"2021","journal-title":"Chinese J Pediatr"},{"key":"2023011712231377500_lam13790-bib-0028","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/irv.12782","article-title":"Adenovirus infection in children hospitalized with pneumonia in Guangzhou, China","volume":"15","author":"Zou","year":"2021","journal-title":"Infiuenza Other Respir Viruses"}],"container-title":["Letters in Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/lam.13790","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/lam.13790","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/lambio\/article-pdf\/75\/5\/1225\/48737821\/lambio1225.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/lambio\/article-pdf\/75\/5\/1225\/48737821\/lambio1225.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T17:28:57Z","timestamp":1673976537000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/lambio\/article\/75\/5\/1225\/6989357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/lam.13790","relation":{},"ISSN":["1472-765X","0266-8254"],"issn-type":[{"type":"electronic","value":"1472-765X"},{"type":"print","value":"0266-8254"}],"subject":[],"published-other":{"date-parts":[[2022,11,1]]},"published":{"date-parts":[[2022,11,1]]}}}