{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:07:38Z","timestamp":1777651658412,"version":"3.51.4"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Extended-spectrum \u03b2-lactamase (ESBL)-producing Enterobacteriaceae have emerged as important nosocomial pathogens. Community infections by these organisms have been also reported and were associated with previous intestinal colonization. We aimed to characterize cefotaxime-resistant Enterobacteriaceae (CTX-R-En) isolated from hospitalized children in a Tunisian paediatric ward. Seventy CTX-R-En isolates were collected from 227 rectal swabs from hospitalized children in a paediatric ward. Antimicrobial susceptibility testing was determined according to the EUCAST guidelines. Isolates were characterized by polymerase chain reaction (PCR, genes encoding: ESBLs, pAmpC, carbapenemases, plasmid-mediated quinolone resistance, virulence factors in Escherichia coli and Klebsiella pneumoniae isolates, occurrence of classes 1 and 2 integrons, phylogenetic groups of E. coli isolates, ERIC-PCR and PCR-based replicon typing) and conjugal transfer experiments. In total, 65 out of 227 (28\u00b76%) hospitalized children were colonized with CTX-M-R-En, and 70 isolates were identified. Isolates were 59 ESBL-, 7 plasmidic-AmpC (pAmpC)-, 3 ESBL+pAmpC-, and one ESBL+carbapenemase producers. The following bla genes were identified: blaCTX-M-15 (n = 54), blaCTX-M-1 (n = 5), blaCTX-M-9 (n = 2), blaCTX-M-13 (n = 1) and blaCTX-M-14 (n = 1), blaCMY-2 (n = 5), blaCMY-4 (n = 4), blaACC-1 (n = 1) and blaOXA-48 (n = 1). Our results showed that hospitalized children were colonized with various CTX-R-En-producing several beta-lactamase enzymes.<\/jats:p>","DOI":"10.1111\/lam.13812","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T01:54:35Z","timestamp":1660960475000},"page":"1460-1474","source":"Crossref","is-referenced-by-count":9,"title":["Genetic heterogeneity and predominance of blaCTX-M-15 in cefotaxime-resistant Enterobacteriaceae isolates colonizing hospitalized children in Tunisia"],"prefix":"10.1093","volume":"75","author":[{"given":"S.","family":"Harbaoui","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine de Tunis LR99ES09 Laboratoire de recherche \u00ab R\u00e9sistance aux antimicrobiens \u00bb, Universit\u00e9 de Tunis El Manar Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ferjani","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine de Tunis LR99ES09 Laboratoire de recherche \u00ab R\u00e9sistance aux antimicrobiens \u00bb, Universit\u00e9 de Tunis El Manar Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9673-193X","authenticated-orcid":false,"given":"M.S.","family":"Abbassi","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine de Tunis LR99ES09 Laboratoire de recherche \u00ab R\u00e9sistance aux antimicrobiens \u00bb, Universit\u00e9 de Tunis El Manar Tunis Tunisia"},{"name":"Institut de la recherche v\u00e9t\u00e9rinaire de Tunisie, Universit\u00e9 de Tunis El Manar Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Saidani","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine de Tunis LR99ES09 Laboratoire de recherche \u00ab R\u00e9sistance aux antimicrobiens \u00bb, Universit\u00e9 de Tunis El Manar Tunis Tunisia"},{"name":"Service de Microbiologie CHU Charles Nicolle Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Gargueh","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie CHU Charles Nicolle Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ferjani","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie CHU Charles Nicolle Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hammi","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie CHU Charles Nicolle Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Boutiba-Ben Boubaker","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine de Tunis LR99ES09 Laboratoire de recherche \u00ab R\u00e9sistance aux antimicrobiens \u00bb, Universit\u00e9 de Tunis El Manar Tunis Tunisia"},{"name":"Service de Microbiologie CHU Charles Nicolle Tunis 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