{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:24:36Z","timestamp":1740126276894,"version":"3.37.3"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to evaluate the performance of accelerated hydrogen peroxide\u00ae wipes (HPW) for decontamination of the chimpanzee adenovirus AZD1222 vaccine strain used in the production of recombinant COVID-19 vaccine in a pharmaceutical industry. Two matrices were tested on stainless-steel (SS) and low-density-polyethylene (LDP) surfaces: formulated recombinant COVID-19 vaccine (FCV) and active pharmaceutical ingredient (API). The samples were spiked, dried and the initial inoculum, possible residue effect (RE) and titre reduction after disinfection with HPW were determined. No RE was observed. The disinfection procedure with HPW resulted in complete decontamination the of AZD1222 adenovirus strain in FCV (\u22657\u00b746 and \u22657\u00b749 log10 infectious unit [IFU] ml\u22121 for SS and LDP carriers respectively) and API (\u22658\u00b779 and \u22658\u00b778 log10 IFU ml\u22121 for SS and LDP carriers respectively). In conclusion, virucidal activity of HPW was satisfactory against the AZD1222 adenovirus strain and can be a good option for disinfection processes of SS and LPD surfaces in pharmaceutical industry facilities during recombinant COVID-19 vaccine production. This procedure is simple and can be also applied on safety unit cabins and sampling bags made of LDP as well.<\/jats:p>","DOI":"10.1111\/lam.13831","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T06:50:44Z","timestamp":1662619844000},"page":"1639-1644","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of hydrogen peroxide wipes for decontamination of AZD1222 adenovirus COVID-19 vaccine strain on pharmaceutical industry materials"],"prefix":"10.1093","volume":"75","author":[{"given":"V.P.","family":"Rhodes","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology Control, Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.C.F.B.","family":"Ajorio","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control, Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.V.","family":"da Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control, Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control, Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.A.","family":"Diniz","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control, Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.V.","family":"da Silva Lage","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control, Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.B.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control, Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1121-7312","authenticated-orcid":false,"given":"M.L.L.","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Control, Department of Quality Control Bio-Manguinhos\/Fiocruz Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"2023011712232821700_lam13831-bib-0001","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/lam.13635","article-title":"Evaluation of hydrogen peroxide efficacy against AZD1222 chimpanzee adenovirus strain in the recombinant COVID-19 vaccine for 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