{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:46:55Z","timestamp":1788871615358,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T00:00:00Z","timestamp":1346976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009974","name":"Cardinal Tien Hospital","doi-asserted-by":"crossref","award":["NTUH 97-TY-02"],"award-info":[{"award-number":["NTUH 97-TY-02"]}],"id":[{"id":"10.13039\/501100009974","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2012,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Biliary atresia (\n BA<\/jats:styled-content>\n ) is a paediatric cholestatic disease characterized by a progressive fibro\u2010inflammation of the biliary tree. Current treatment of choice is to establish good bile flow via the Kasai operation.\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n We aimed to identify outcome\u2010predictive serum biomarkers in BA infant.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Thirty\u2010three\n BA<\/jats:styled-content>\n children recruited from 1986 to 2007 served as the baseline\u2010study group. An additional 11 children recruited from 2008 to 2011 served as the validation group. Serum samples were collected immediately before and 6\u00a0months after the Kasai operation for the assessment of serum cytokines, including tumour necrosis factor\u2010\u03b1 (\n TNF<\/jats:styled-content>\n \u2010\u03b1), transforming growth factor\u2010\u03b2 (\n TGF<\/jats:styled-content>\n \u2010\u03b2), interferon\u2010\u03b3 (\n IFN<\/jats:styled-content>\n \u2010\u03b3), interleukin\u20102 (\n IL<\/jats:styled-content>\n \u20102),\n IL<\/jats:styled-content>\n \u201010,\n IL<\/jats:styled-content>\n \u201012p40 and\n IL<\/jats:styled-content>\n \u201012p70 as the candidate biomarkers.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Increased serum TGF\u2010\u03b2 levels indicated a lower Knodell hepatitis activity index at Kasai operation. The serum TGF\u2010\u03b2 levels declined after the operation. Serum IL\u201012p40 levels before the Kasai operation were higher in the subjects with a 3\u2010month jaundice\u2010free status than in others (\n P\u00a0<\/jats:italic>\n =\u00a00.001). A serum pre\u2010operative IL\u201012p40 level of 33\u00a0pg\/ml was predictive of a 3\u2010month jaundice\u2010free status after surgery (positive predictive value=81.0%; negative predictive value=83.3%). This biomarker was also predictive of a better outcome, in terms of 3\u2010year survival with native liver (risk ratio [RR\u00a0=\u00a04.00];\n P<\/jats:italic>\n \u00a0<\u00a00.001), and 3\u2010year jaundice\u2010free survival with native liver (RR\u00a0=\u00a012.00;\n P<\/jats:italic>\n \u00a0<\u00a00.001). We confirmed the predictive power of a high pre\u2010operative IL\u201012p40 level on 3\u2010month jaundice\u2010free status in the validation group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The pre\u2010operative\n IL<\/jats:styled-content>\n \u201012p40 level was a good predictive biomarker of clinical outcome in children with\n BA<\/jats:styled-content>\n undergoing the Kasai operation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.12001","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T08:44:50Z","timestamp":1347007490000},"page":"1557-1563","source":"Crossref","is-referenced-by-count":14,"title":["A high serum interleukin\u201012p40 level prior to Kasai surgery predict a favourable outcome in children with biliary atresia"],"prefix":"10.1111","volume":"32","author":[{"given":"Jia\u2010Feng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Chi","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Cardinal Tien Hospital Yung Ho Branch New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huey\u2010Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Shiee","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Yuan","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital Taipei 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