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We studied the performance of\n                      <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>\n                      for detection of significant portal hypertension, oesophageal varices and large oesophageal varices using meta\u2010analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PubMed, the Cochrane Library,\n                      <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">ISI<\/jats:styled-content>\n                      web of Knowledge were searched. The studies published in English relating to the diagnostic value of\n                      <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>\n                      for significant portal hypertension, oesophageal varices and large oesophageal varices in patients with\n                      <jats:styled-content style=\"fixed-case\">CLD<\/jats:styled-content>\n                      were collected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 18 studies, which included 3644 patients were analysed. Summary sensitivity and specificity were 0.90 (95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ), 0.81\u20130.95) and 0.79 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 0.58\u20130.91) for significant portal hypertension, and 0.87 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 0.80\u20130.92) and 0.53 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 0.36\u20130.69) for oesophageal varices and 0.86 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 0.71\u20130.94) and 0.59 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 0.45\u20130.72) for large oesophageal varices respectively. The\n                      <jats:styled-content style=\"fixed-case\">HSROC<\/jats:styled-content>\n                      s were 0.93 for significant portal hypertension, 0.84 for oesophageal varices and 0.78 for large oesophageal varices respectively.\n                      <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>\n                      was very informative with 81% probability of correctly detection significant portal hypertension following a \u2018positive\u2019 measurement (over the threshold value) and lowering the probability of disease to as low as 11% when \u2018negative\u2019 measurement (below the threshold value) when pre\u2010test probability was 50% whereas, for oesophageal varices or large oesophageal varices, the probability of a correct diagnosis following a \u2018positive\u2019 measurement did not exceeded 70%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>\n                      could be used as a good screening tool for significant portal hypertension, but only moderate diagnostic utility for the prediction of oesophageal varices or large oesophageal varices.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.12003","type":"journal-article","created":{"date-parts":[[2012,9,14]],"date-time":"2012-09-14T23:38:14Z","timestamp":1347665894000},"page":"62-71","source":"Crossref","is-referenced-by-count":170,"title":["Transient elastography: a meta\u2010analysis of diagnostic accuracy in evaluation of portal hypertension in chronic liver disease"],"prefix":"10.1111","volume":"33","author":[{"given":"Ke\u2010Qing","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Infection and Liver Diseases Liver Research Center , The First Affiliated Hospital of Wenzhou Medical College Wenzhou China"},{"name":"Institute of Hepatology Wenzhou Medical College Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hepatology Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010Zhen","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Infection and Liver Diseases Liver Research Center , The First Affiliated Hospital of Wenzhou Medical College Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Infection and Liver Diseases Liver Research Center , The First Affiliated Hospital of Wenzhou Medical College Wenzhou China"},{"name":"School of the First Clinical Medical Sciences Wenzhou Medical College Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infection and Liver Diseases Liver Research Center , The First Affiliated Hospital of Wenzhou Medical College Wenzhou China"},{"name":"School of the First Clinical Medical Sciences Wenzhou Medical College Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infection and Liver Diseases Liver Research Center , The First Affiliated Hospital of Wenzhou Medical College Wenzhou China"},{"name":"Institute of Hepatology Wenzhou Medical College Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hua","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infection and Liver Diseases Liver Research Center , The First Affiliated Hospital of Wenzhou 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