{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:47:51Z","timestamp":1787503671472,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Apelin\u2010\n                      <jats:styled-content style=\"fixed-case\">APJ<\/jats:styled-content>\n                      signalling is known to play important roles in heart physiology and pathology; however, its functions in liver physiology and pathology remain unclear. On the other hand, Fas is an important molecule in hepatitis and other liver disease that belongs to the death receptor family. The aim of this study was to assess the relationship between apelin\u2010\n                      <jats:styled-content style=\"fixed-case\">APJ<\/jats:styled-content>\n                      signaling and Fas\u2010mediated liver injury in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">APJ<\/jats:styled-content>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice and wild type (\n                      <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>\n                      ) mice were administered an intraperitoneal injection of an agonistic anti\u2010Fas antibody (clone; Jo2), and sacrificed after 3 or 6\u00a0h to assess the liver histology. The expression levels of apelin and\n                      <jats:styled-content style=\"fixed-case\">APJ<\/jats:styled-content>\n                      , plasma levels of transaminases, activities of hepatic caspases and activations of stress\u2010activated protein kinases were also analysed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Before the Jo2 injection,\n                      <jats:styled-content style=\"fixed-case\">APJ<\/jats:styled-content>\n                      was weakly expressed in the hepatocytes in spots; on the other hand, after the Jo2 injection, it had spread into whole hepatocytes. Moreover, the\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      expression level of apelin and\n                      <jats:styled-content style=\"fixed-case\">APJ<\/jats:styled-content>\n                      in the liver increased after Jo2 injection. In the\n                      <jats:styled-content style=\"fixed-case\">APJ<\/jats:styled-content>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice, the liver injuries and apoptotic changes were significantly inhibited as compared with those in the\n                      <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>\n                      mice. Dramatic increase in\n                      <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>\n                      activation was observed in the\n                      <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>\n                      mice after Jo2 injection, whereas such activation was completely absent in the\n                      <jats:styled-content style=\"fixed-case\">APJ<\/jats:styled-content>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice.\n                      <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>\n                      inhibitor partially, but significantly suppressed Jo2\u2010mediated liver injury in\n                      <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>\n                      mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Apelin\u2010\n                      <jats:styled-content style=\"fixed-case\">APJ<\/jats:styled-content>\n                      signalling may promote Fas\u2010induced liver injury at least partially via\n                      <jats:styled-content style=\"fixed-case\">JNK<\/jats:styled-content>\n                      activation, and may thus serve as a potential therapeutic target in cases of acute liver injury.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.12006","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T22:52:55Z","timestamp":1351810375000},"page":"118-126","source":"Crossref","is-referenced-by-count":26,"title":["Involvement of the apelin receptor\n                    <scp>APJ<\/scp>\n                    in Fas\u2010induced liver injury"],"prefix":"10.1111","volume":"33","author":[{"given":"Hiroaki","family":"Yasuzaki","sequence":"first","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010ichirou","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Shibata","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Yokohama City University Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Inamori","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Yokohama City University Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Toya","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Maeda","sequence":"additional","affiliation":[{"name":"Gastroenterology Division Yokohama City University Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Umemura","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(93)90495-O"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9489"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.04.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M908417199"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(00)00143-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.08.018"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070471"},{"key":"e_1_2_7_9_1","first-page":"3343","article-title":"Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis","volume":"118","author":"Chun HJ","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(99)00114-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.7.6113-6118.1998"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210573"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.10.042"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22467"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.234690"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.3.G354"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1223"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100740200"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)00063-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4765"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100444200"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215077"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.05.021"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00355-6"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27726"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.10.005"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404149200"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.11.015"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.027"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-019-5_13"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.12.023"},{"key":"e_1_2_7_32_1","first-page":"285","article-title":"The neuronal isoform of constitutive nitric oxide synthase is up\u2010regulated in the macula densa of angiotensinogen gene\u2010knockout mice","volume":"76","author":"Kihara M","year":"1997","journal-title":"Lab Invest"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317970"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.33.1.29"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2011.00945.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.021"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.03.008"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0771fje"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24357"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.12006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T23:52:57Z","timestamp":1700610777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.12006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/liv.12006"],"URL":"https:\/\/doi.org\/10.1111\/liv.12006","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}