{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:47:49Z","timestamp":1780530469003,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antibodies to soluble liver antigen (anti\u2010<jats:styled-content style=\"fixed-case\">SLA<\/jats:styled-content>) are specific serological markers of autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>). The clinical significance and frequency of anti\u2010<jats:styled-content style=\"fixed-case\">SLA<\/jats:styled-content> have never been reported among <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients from Italy and Turkey.<\/jats:p><jats:p>To retrospectively assess the estimated prevalence, sensitivity, specificity and clinical significance of anti\u2010<jats:styled-content style=\"fixed-case\">SLA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> and various liver diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 986 patients who had been tested for serum anti\u2010<jats:styled-content style=\"fixed-case\">SLA<\/jats:styled-content> were included in study. The presence of anti\u2010<jats:styled-content style=\"fixed-case\">SLA<\/jats:styled-content> was detected using recombinant enzyme linked immunosorbent assay and immuno\u2010blot. The general characteristics and outcome of patients were obtained from their medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Antibodies to <jats:styled-content style=\"fixed-case\">SLA<\/jats:styled-content> were found in 30 (3%) of 986 patients. Of these, 27 (90%) had <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> and its variants, whereas the remaining three (10%) had primary biliary cirrhosis. The prevalence of anti\u2010<jats:styled-content style=\"fixed-case\">SLA<\/jats:styled-content> was 9% in <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients from Italy and 15% in patients from Turkey. The specificity of these antibodies was 99.5%, whereas sensitivity was 11%. The positive predictive and negative predictive values were 90% and 77.5% respectively (95% confidence interval). Biochemical remission was achieved in 90% of anti\u2010<jats:styled-content style=\"fixed-case\">SLA<\/jats:styled-content> positive <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients, but relapse after immunosuppressive withdrawal or during maintenance therapy was observed in 53% of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Seropositivity for anti\u2010<jats:styled-content style=\"fixed-case\">SLA<\/jats:styled-content> occurs at similar frequencies in <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients from different geographical regions and ethnic groups. The sensitivity of anti\u2010<jats:styled-content style=\"fixed-case\">SLA<\/jats:styled-content> is low, but it has high specificity for <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>. Additional studies are necessary to prove clinical significance of anti\u2010<jats:styled-content style=\"fixed-case\">SLA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12022","type":"journal-article","created":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T22:32:03Z","timestamp":1350513123000},"page":"190-196","source":"Crossref","is-referenced-by-count":32,"title":["Antibodies to soluble liver antigen in patients with various liver diseases: A multicentre study"],"prefix":"10.1111","volume":"33","author":[{"given":"Cumali","family":"Efe","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Numune Research and Education Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersan","family":"Ozaslan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Numune Research and Education Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Wahlin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugrul","family":"Purnak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Numune Research and Education Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Muratori","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Alma Mater Studiorum, University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Quarneti","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Alma Mater Studiorum, University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ankara Diskapi Education and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Muratori","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Alma Mater Studiorum, University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23584"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22322"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.053"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2012.02.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.10.012"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1501-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.2.259"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.10.013"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.32092"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80342-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8411(03)00084-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80361-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280203"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.4.589"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.11.027"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23294"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.04.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22261"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04320.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/0891693021000064272"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02166-8"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92024-1"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/0891693021000056712"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80477-1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1997.4071302.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.01986.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1740-2557-4-2"},{"key":"e_1_2_6_29_1","first-page":"527","article-title":"Relation between autoimmune liver diseases and viral hepatitis: clinical and serological characteristics in 859 patients","volume":"33","author":"Lohse AW","year":"1995","journal-title":"Z Gastroenterol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0705-9"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1611-4"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.4318\/tjg.2011.0245"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23588"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24481"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23834"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.024"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.12.041"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02150.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.6.893"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00479.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250211"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.4318\/tjg.2011.0155"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05479.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02502.x"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12022","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.12022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T05:06:59Z","timestamp":1697260019000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.12022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,7]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/liv.12022"],"URL":"https:\/\/doi.org\/10.1111\/liv.12022","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,7]]}}}