{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:14:29Z","timestamp":1791688469082,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T00:00:00Z","timestamp":1352678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aims<\/jats:title>\n                    <jats:p>\n                      The term overlap syndrome describes variant forms of autoimmune hepatitis (\n                      <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>\n                      ) that present in combination with either characteristics of primary biliary cirrhosis (\n                      <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>\n                      ), or primary sclerosing cholangitis (\n                      <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\n                      ). This study analysed the outcomes and evidence of recurrent liver disease after liver transplantation in patients with overlap syndromes compared with patients transplanted for single autoimmune liver disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We evaluated 231 adult patients who received a liver transplant as a result of autoimmune liver diseases; including 103 with\n                      <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>\n                      , 84 with\n                      <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\n                      , 32 with\n                      <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>\n                      and 12 with overlap syndrome (7\n                      <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>\n                      and 5\n                      <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with overlap syndromes had a higher probability of recurrence than patients with a single autoimmune liver disease (5\u00a0years: 53% vs. 17%; 10\u00a0years 69% vs. 29%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001). Furthermore, median time for recurrence in overlap syndrome was shorter when compared with patients with single autoimmune liver disease (67\u00a0\u00b1\u00a020 vs. 172\u00a0\u00b1\u00a09\u00a0months,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001). The diagnosis of overlap syndrome was independently associated with a higher risk to develop recurrent disease than patients transplanted with a single disease (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      3.39,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007). Median graft survival for overlap syndrome was 123\u00a0\u00b1\u00a016\u00a0months and 180\u00a0\u00b1\u00a08\u00a0months in patients with single autoimmune liver diseases (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.9), and median patient survival for overlap syndrome was 135\u00a0\u00b1\u00a013\u00a0months and 193\u00a0\u00b1\u00a08\u00a0months in patients with single autoimmune liver disease (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.6).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients that received an allograft for end\u2010stage liver disease secondary to overlap syndrome had a higher rate of disease recurrence when compared with transplant recipients with single autoimmune liver disorders, but the overall survival was comparable.<\/jats:p>\n    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