{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:25:48Z","timestamp":1784129148167,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary sclerosing cholangitis (<jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content>) is a chronic cholestatic liver disease. It is known to be associated with immunological diseases (<jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>s), such as inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>) and autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We evaluated the presence of <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>s besides <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> in a cohort of <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> patients, and its association with clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective cohort study of 195 <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> patients that were evaluated over the period 1987\u20132010 in our tertiary care centre. The presence of <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content> was determined using a retrospective chart review. <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>s were subclassified into autoimmune disease (<jats:styled-content style=\"fixed-case\">AID<\/jats:styled-content>) and immune\u2010mediated inflammatory disease (<jats:styled-content style=\"fixed-case\">IMID<\/jats:styled-content>), according to current guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven of 195 (13.8%) <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> patients had at least one additional <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content> other than <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> (70%) or <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> (5%). The most frequent <jats:styled-content style=\"fixed-case\">AID<\/jats:styled-content>s were autoimmune thyroiditis (2.6%) and diabetes mellitus type 1 (2.1%). The most frequent <jats:styled-content style=\"fixed-case\">IMID<\/jats:styled-content>s were psoriasis (3.6%) and sarcoidosis (2.1%). After more than 20\u00a0years of follow\u2010up, concomitant <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>s represent an independent risk factor for reduced transplantation\u2010free survival in patients with <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> (mean: 8.9\u00a0years vs. 16.3\u00a0years, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.012). Further subgroup analysis revealed a significantly reduced survival especially in patients with concomitant <jats:styled-content style=\"fixed-case\">IMID<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with concomitant <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content>s, especially <jats:styled-content style=\"fixed-case\">IMID<\/jats:styled-content>, are a clinically important subgroup of <jats:styled-content style=\"fixed-case\">PSC<\/jats:styled-content> patients. This significant phenotype warrants further genetic and immunological studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12028","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T10:30:27Z","timestamp":1350037827000},"page":"86-93","source":"Crossref","is-referenced-by-count":25,"title":["Non\u2010<scp>IBD<\/scp> immunological diseases are a risk factor for reduced survival in <scp>PSC<\/scp>"],"prefix":"10.1111","volume":"33","author":[{"given":"Christian","family":"Rupp","sequence":"first","affiliation":[{"name":"Department of Internal Medicine IV University Hospital of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Mummelthei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV University Hospital of Heidelberg Heidelberg 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