{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:17:19Z","timestamp":1792289839470,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T00:00:00Z","timestamp":1360627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Iron overload and hepatitis\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection, have been implicated in the evolution of liver disease, in patients with transfusion\u2010dependent beta\u2010thalassaemia major (<jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content>). However, the impact of these factors in late stages of liver disease in adults with<jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content>, has not been extensively studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate serum indices of iron overload,<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>infection and liver disease, in a cohort of 211 adult<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>reek patients with<jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content>, in relation with the findings from liver biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, 211 patients with<jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content>were enrolled and studied, in relation with<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>infection, ferritin, transaminases, chelation treatment and antiviral treatment. Based on<jats:styled-content style=\"fixed-case\">109<\/jats:styled-content>patients biopsied, we correlated liver fibrosis, haemosiderosis and inflammation, with serum indices and<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>status<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among all patients, 74.4% were anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>positive (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>+). Ferritin was positively correlated with transaminases and negatively correlated with age, while it was not significantly different among<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>V+ and<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2212 patients. Among the<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>+ patients, 55.4% reported antiviral treatment, while genotype 1 predominated. In a subfraction of 109 patients, in which liver biopsy was performed, 89% were<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>+ and 11%<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2212. Fibrosis was significantly correlated with age (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.046), AST (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), ALT (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.044) and inflammation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Advanced fibrosis was present with even minimal haemosiderosis, independently of ferritin values or<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that in the late stages of liver disease in<jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content>patients, iron overload may be the critical determinant, since fibrosis is related to the minimal haemosiderosis, independently of<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>history.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12095","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T01:18:18Z","timestamp":1360718298000},"page":"420-427","source":"Crossref","is-referenced-by-count":14,"title":["Liver disease in adult transfusion\u2010dependent beta\u2010thalassaemic patients: investigating the role of iron overload and chronic HCV 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