{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:30:31Z","timestamp":1792798231342,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T00:00:00Z","timestamp":1363132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["01EO0802"],"award-info":[{"award-number":["01EO0802"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Robert Koch Institute on hepatitis E","award":["1362-1097"],"award-info":[{"award-number":["1362-1097"]}],"id":[{"id":"https:\/\/ror.org\/01k5qnb77","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The role of ribavirin for treatment of severe acute or chronic hepatitis E virus (\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      ) infection is not well defined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To investigate the applicability and efficacy of ribavirin therapy in acute and chronic\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      infections within a large single\u2010centre cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials &amp; Methods<\/jats:title>\n                    <jats:p>\n                      Clinical courses of forty\u2010four German\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      \u2010infected individuals were analysed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In a prospective case series, we observed spontaneous recovery from acute symptomatic\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      \u2010infection in 10\/11 immunocompetent individuals. Ribavirin therapy was initiated in one patient with severe acute\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      \u2010genotype\u20101e infection who rapidly improved liver function and cleared\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      . Of 15 organ transplant recipients with prolonged\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      viraemia, reduction in immunosuppression led to\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      \u2010clearance in three patients, while ribavirin therapy was initiated in 11 subjects. A rapid response with undetectable\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                      occurred in nine subjects. One patient died after experiencing a virological breakthrough associated with ribavirin dose reduction because of severe anaemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Ribavirin is a safe treatment option for\n                      <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                      infections. However, the optimal dose of ribavirin for the treatment of chronic hepatitis E remains to be determined as treatment failure may occur.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.12114","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T01:55:54Z","timestamp":1359338154000},"page":"722-726","source":"Crossref","is-referenced-by-count":174,"title":["Ribavirin treatment of acute and chronic hepatitis E: a single\u2010centre experience"],"prefix":"10.1111","volume":"33","author":[{"given":"Sven","family":"Pischke","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Hannover Germany"},{"name":"IFB\u2010TX Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Hardtke","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Bode","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Birkner","sequence":"additional","affiliation":[{"name":"Praxis Dr Birkner Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Chatzikyrkou","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Kauffmann","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Vivantes Klinikum Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph 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