{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T22:49:43Z","timestamp":1771886983978,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Hospital mortality secondary to cirrhosis is high.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate hospital mortality in patients admitted for specific complications of cirrhosis over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Registry\u2010data from Administrative Inpatient Dataset of acute care hospitals were collected at discharge from 2003 to 2010. Inclusion criteria were as follows: hospital admissions where one of the diagnoses was cirrhosis and the reason for admission was a specific complication of cirrhosis (ascites, encephalopathy, hepatorenal syndrome and haemorrhage from varices, bacterial spontaneous peritonitis). Analysis of variance was used for comparisons of quantitative variables and Chi\u2010square for qualitative variables. Logistic regression was performed to identify the risk factors associated with hospital mortality; the Hosmer and Lemeshow test was applied to evaluate calibration and the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve for discrimination respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 12,671 hospital admissions were analysed; 67.7% were men. Mean hospitalization stay was 10.9 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 9.2)\u00a0days and the most frequent causes were encephalopathy (44.2%) and ascites (30.9%). Global hospital mortality was 11.6%. Logistic regression showed that once all factors had been adjusted, hepatorenal syndrome conveyed the highest risk for death (49.2%; OR\u00a0=\u00a08.1(95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>:6.6\u20139.9). Risk of death was also increased by associated comorbidities and older age. Hospital mortality in the period 2006\u20132010 was 27% inferior to the period 2003\u20132005. The area under the ROC curve (<jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content>) was 0.77 (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.76\u20130.78).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hospital mortality as a result of specific complications of cirrhosis is high, but has been declining in recent years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12137","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T16:47:24Z","timestamp":1361551644000},"page":"828-833","source":"Crossref","is-referenced-by-count":36,"title":["Hospital mortality over time in patients with specific complications of cirrhosis"],"prefix":"10.1111","volume":"33","author":[{"given":"Mercedes","family":"Vergara","sequence":"first","affiliation":[{"name":"Digestive Diseases Unit Hospital de Sabadell Universitat Aut\u00f2noma de Barcelona Sabadell Spain"},{"name":"Instituto de Salud Carlos III 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