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Moreover, <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> (1\u00a0\u03bcM and 10\u00a0\u03bcM) increased osteoblast differentiation in cells treated with harmful concentrations of <jats:styled-content style=\"fixed-case\">LCA<\/jats:styled-content> or bilirubin. <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> (100\u00a0\u03bcM) increased cell differentiation in osteoblasts cultured with a mix of serum from cholestatic patients by 23%. Furthermore, <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> increased osteoblast mineralization by 35% and neutralized the negative consequences of 50\u00a0\u03bcM bilirubin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> increases osteoblast differentiation and mineralization, and neutralizes the detrimental effects of lithocholic acid, bilirubin and sera from jaundiced patients on osteoblastic cells. Therefore, <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> may exert a favourable effect on bone in patients which chronic cholestasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12153","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T18:51:06Z","timestamp":1362163866000},"page":"1029-1038","source":"Crossref","is-referenced-by-count":31,"title":["Ursodeoxycholic acid increases differentiation and mineralization and neutralizes the damaging effects of bilirubin on osteoblastic cells"],"prefix":"10.1111","volume":"33","author":[{"given":"Marta","family":"Dubreuil","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) University of Barcelona Barcelona Spain"},{"name":"Metabolic Bone Diseases Unit Department of Rheumatology University of Barcelona Barcelona Spain"},{"name":"Liver Unit Digestive Diseases Institute Hospital Cl\u00ednic 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