{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:24:30Z","timestamp":1772763870350,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,24]],"date-time":"2013-03-24T00:00:00Z","timestamp":1364083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoantibodies to ribosomal P proteins (anti\u2010rib P) are specific serological markers for systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>) and are associated with liver involvement in this disease. The similarity in autoimmune background between autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>\u2010associated hepatitis raises the possibility that anti\u2010rib P antibodies might also have relevance in <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the frequency and clinical significance of anti\u2010rib P antibodies in a large <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sera obtained at diagnosis of 96 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients and of 82 healthy controls were tested for <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content> anti\u2010ribosomal P protein by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. All of the sera were also screened for other lupus\u2010specific autoantibodies, three patients with the presence of anti\u2010ds<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) and anti\u2010Sm (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Moderate to high titres (&gt;40\u00a0U) of anti\u2010rib P antibody were found in 9.7% (9\/93) of the <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients and none of the controls (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003). At presentation, <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients with and without anti\u2010rib P antibodies had similar demographic\/clinical features, including the frequency of cirrhosis (44.4 vs. 28.5%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.44), hepatic laboratorial findings (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Importantly, at the final observation (follow\u2010up period 10.2\u00a0\u00b1\u00a04.9\u00a0years), the <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients with anti\u2010rib P had a significantly higher frequency of cirrhosis compared with the negative group (100 vs. 60%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The novel demonstration of anti\u2010rib P in <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients without clinical or laboratory evidence of <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> suggests a common underlying mechanism targeting the liver in these two diseases. In addition, this antibody appears to predict the patients with worse <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> prognoses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12155","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T15:19:04Z","timestamp":1362583144000},"page":"909-913","source":"Crossref","is-referenced-by-count":39,"title":["Anti\u2010ribosomal <scp>P<\/scp> protein: a novel antibody in autoimmune hepatitis"],"prefix":"10.1111","volume":"33","author":[{"given":"Ana L.","family":"Calich","sequence":"first","affiliation":[{"name":"Division of Rheumatology University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilma S. T.","family":"Viana","sequence":"additional","affiliation":[{"name":"Division of Rheumatology University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Cancado","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Tustumi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora R. B.","family":"Terrabuio","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine P.","family":"Leon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clovis A.","family":"Silva","sequence":"additional","affiliation":[{"name":"Division of Rheumatology University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"},{"name":"Pediatric Rheumatology Unit University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo F.","family":"Borba","sequence":"additional","affiliation":[{"name":"Division of Rheumatology University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloisa","family":"Bonfa","sequence":"additional","affiliation":[{"name":"Division of Rheumatology University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180435"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200310000-00011"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.08.002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02658.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02502.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950070607"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02686080"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0889-857X(21)00733-X","article-title":"Antiribosomal antibodies in systemic lupus erythematosus","volume":"18","author":"Elkon KB","year":"1992","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290806"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.06.004"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1995.1037"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.07.004"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.4049\/jimmunol.159.4.2033","article-title":"Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture","volume":"159","author":"Koscec M","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-3212-1"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2003.11.008"},{"key":"e_1_2_5_18_1","first-page":"1681","article-title":"Autoantibodies against ribosomal proteins found with high frequency in patients with systemic lupus erythematosus with active disease","volume":"18","author":"Sato T","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-387025-4.00005-4"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00304496"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230525"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021933"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.08.014"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1999.0300"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.13.1.77-83.2006"},{"key":"e_1_2_5_27_1","first-page":"403","article-title":"Anti\u2010ribosomal\u2010P antibodies in lupus patients and healthy controls: evaluation of three ELISA assays","volume":"11","author":"Agmon\u2010Levin N","year":"2009","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2002.0595"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198707303170503"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21875"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu209oa"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360917"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115707"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20869"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-010-0354-y"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2011.09.009"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12155","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.12155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T01:54:52Z","timestamp":1700618092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.12155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,24]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/liv.12155"],"URL":"https:\/\/doi.org\/10.1111\/liv.12155","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,24]]}}}