{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:43:03Z","timestamp":1776861783588,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,7]],"date-time":"2013-04-07T00:00:00Z","timestamp":1365292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Quantification of liver stiffness with transient elastography (<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>) is validated for staging hepatic fibrosis in chronic hepatitis C infection. The current study was aimed to assess the diagnostic performance of liver stiffness measurement for the determination of fibrosis stage in patients with chronic pancreatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty consecutive patients with chronic pancreatitis and increased liver enzyme were enrolled over a 2.5\u2010year period. Eight liver living donor candidates were recruited to serve as internal controls. The <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> values were compared with non\u2010invasive fibrosis scoring systems including aspartate transaminase (AST)\/alanine aminotransferase (ALT) ratio, <jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content>, non\u2010alcoholic fatty liver disease <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> score, <jats:styled-content style=\"fixed-case\">FIB<\/jats:styled-content>\u20104 index and to liver histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TE was successful in all patients. Stiffness values ranged from 3.1 to 69\u00a0kPa (mean 16.9). Liver stiffness was correlated with fibrosis stage (Spearman's correlation 0.73, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). Areas under receiver operator characteristics curves for fibrosis <jats:italic><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4 were 0.92 for <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>, 0.87 for <jats:styled-content style=\"fixed-case\">FIB<\/jats:styled-content>\u20104 index, 0.81 for <jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content>, 0.73 for <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> score and 0.71 for <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> ratio. Optimal stiffness cut\u2010off values for diagnosis fibrosis <jats:italic><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4 was 10.9\u00a0kPa, with 90% sensitivity, 85% specificity and 86% accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study provides for the first time evidence that liver stiffness in patients with chronic pancreatitis and concomitant cholestasis can be measured by <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12163","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T05:23:06Z","timestamp":1364188986000},"page":"1121-1127","source":"Crossref","is-referenced-by-count":5,"title":["The role of transient elastography in the detection of liver disease in patients with chronic pancreatitis"],"prefix":"10.1111","volume":"33","author":[{"given":"Jean 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