{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:01:19Z","timestamp":1790492479264,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,21]],"date-time":"2013-04-21T00:00:00Z","timestamp":1366502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sorafenib is an orally active multikinase inhibitor approved for the treatment of advanced hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>). However, clinical parameters that may predict the treatment outcomes in sorafenib\u2010treated advanced <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 99 advanced (<jats:styled-content style=\"fixed-case\">BCLC<\/jats:styled-content> C) <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients treated with sorafenib as an initial treatment modality from January 2007 to December 2011 were retrospectively reviewed. Overall survival was the primary endpoint for the analysis. Various clinical parameters including tumour stage and adverse effects to sorafenib were analysed. Univariate and multivariate analysis were carried out to identify clinical parameters predictive of the effect of sorafenib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 86 males and 13 females included in this study, with a median age of 53\u00a0years. The median overall survival was 91\u00a0days. Sixty\u2010nine patients had Child\u2010Pugh class A cirrhosis and 30 patients had Child\u2010Pugh class B cirrhosis. Hepatitis B virus was the predominant cause of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> (75.8%). Noted adverse effects were hand\u2010foot syndrome, diarrhoea, fatigue, abdominal pain, nausea and stomatitis. The presence of hand\u2010foot syndrome and diarrhoea and the absence of portal vein thrombosis and lymph node metastasis predicted a better overall survival in the multivariate analysis. Excluding the absence of lymph node metastasis, the same parameters were associated with a longer radiological time to progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Advanced <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients treated with sorafenib who experienced hand\u2010foot syndrome and diarrhoea showed better overall survival than patients without these side effects. These side effects may be used as clinical parameters predictive of sorafenib response in patients with <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12168","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T14:25:10Z","timestamp":1364912710000},"page":"950-957","source":"Crossref","is-referenced-by-count":71,"title":["Clinical parameters predictive of outcomes in sorafenib\u2010treated patients with advanced hepatocellular carcinoma"],"prefix":"10.1111","volume":"33","author":[{"given":"Ju\u2010Yeon","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Han","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Yeong","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Gon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Keun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Won","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geum\u2010Youn","family":"Gwak","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Seok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Hyeok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Cheol","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Woon","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Chul","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70285-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06404.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.12.35"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2175"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-7-41"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04823.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2012.00991.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.001"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02541.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3182468039"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25639"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0143"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25637"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25257"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327591"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333277"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04860.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27543"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-011-1616-x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000136019.94333.09"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23485"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32834bd2d0"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08357.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01059.x"},{"key":"e_1_2_5_29_1","first-page":"889","article-title":"Relationship between sorafenib\u2010associated hand\u2010food skin reaction and efficacy in treatment of advanced hepatocellular carcinoma","volume":"92","author":"Luo XN","year":"2012","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2610"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLC.2006.s.008"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12168","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.12168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T01:55:44Z","timestamp":1700618144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.12168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,21]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/liv.12168"],"URL":"https:\/\/doi.org\/10.1111\/liv.12168","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,21]]}}}