{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:57:57Z","timestamp":1761947877050},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,21]],"date-time":"2013-04-21T00:00:00Z","timestamp":1366502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Coeliac disease patients frequently display mild elevation of liver enzymes and this abnormality usually normalizes after gluten\u2010free diet. To investigate the cause and prevalence of altered liver function tests in coeliac patients, basally and after 1\u00a0year of gluten\u2010free diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Data from 245 untreated <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patients (196 women and 49 men, age range 15\u201380\u00a0years) were retrospectively analysed and the liver function tests before and after diet, as well as associated liver pathologies, were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 43\/245 (17.5%) patients had elevated values of one or both aminotransferases; the elevation was mild (&lt;5 times the upper reference limit) in 41 (95%) and marked (&gt;10 times the upper reference limit) in the remaining 2 (5%) patients. After 1\u00a0year of gluten\u2010free diet, aminotransferase levels normalized in all but four patients with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection or primary biliary cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In coeliac patients, hypertransaminaseaemia at diagnosis and the lack of normalization of liver enzymes after 12\u00a0months of diet suggest coexisting liver disease. In such instance, further evaluation is recommended to exclude the liver disease. Early recognition and treatment of coeliac disease in patients affected by liver disease are important to improve the liver function and prevent complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12178","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T15:52:07Z","timestamp":1364485927000},"page":"1128-1131","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence and causes of abnormal liver function in patients with coeliac disease"],"prefix":"10.1111","volume":"33","author":[{"given":"Giovanni","family":"Casella","sequence":"first","affiliation":[{"name":"Medical Department Desio Hospital Monza and Brianza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Gastroenterology and Hepatology Section University of Perugia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camillo","family":"Di Bella","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Desio Hospital Monza and Brianza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Villanacci","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics Pathology Section Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Fanini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Gastroenterology and Hepatology Section University of Perugia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Baldini","sequence":"additional","affiliation":[{"name":"Medical Department Desio Hospital Monza and Brianza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrio","family":"Bassotti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine Gastroenterology and Hepatology Section University of Perugia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.10.004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010852"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05013.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220322"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290318"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32416"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2004.01.012"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026650118759"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20047"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90954-0"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11222-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199910000-00019"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.03.019"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1040752"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-008-8086-x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.05.013"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200308000-00006"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80618-X"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.06031.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90480-4"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.736"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.09.034"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.1.120"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9360-5"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-2-199907200-00024"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02880-4"},{"key":"e_1_2_5_28_1","first-page":"256","article-title":"Massive hepatic steatosis disclosing adult celiac disease. 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