{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:59:59Z","timestamp":1791849599689,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,4,21]],"date-time":"2013-04-21T00:00:00Z","timestamp":1366502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Various vasoconstrictors have shown promising results in the management of type 1 hepatorenal syndrome (<jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>). However, there are very few studies on vasopressors in the management of type 2 <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>. Terlipressin has been used commonly; however, it is costly and not available in some countries. In this study, we evaluated the safety and efficacy of terlipressin and noradrenaline in the treatment of type 2 <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010six patients with type 2 <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content> were managed with terlipressin (group A, <jats:italic>N<\/jats:italic>\u00a0=\u00a023) or noradrenaline (Group B, <jats:italic>N<\/jats:italic>\u00a0=\u00a023) with albumin in a randomized controlled trial at a tertiary centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content> reversal could be achieved in 17(73.9%) patients in group A as well as in group B (<jats:italic>P<\/jats:italic>\u00a0=\u00a01.0). Univariate analysis showed that the baseline model of end\u2010stage liver disease score, urine output, urinary sodium, serum creatinine and mean arterial pressure were associated with response. However, in multivariate analysis only baseline serum creatinine, urine output and urinary sodium were associated with the response. Eight patients in group A and 9 in group B died within 90\u00a0days of follow\u2010up (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Noradrenaline was less expensive than terlipressin (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). No major adverse effects were seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this randomized study suggest that terlipressin and noradrenaline are safe and effective in the treatment of type 2 <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content> and baseline serum creatinine, urine output and urinary sodium are predictive of response. Noradrenaline is less expensive than terlipressin in the treatment of type 2 <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content> (ClinicalTrials.gov, Number NCT01637454).<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12179","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T15:52:50Z","timestamp":1364485970000},"page":"1187-1193","source":"Crossref","is-referenced-by-count":79,"title":["Noradrenaline vs terlipressin in the treatment of type 2 hepatorenal syndrome: a randomized pilot study"],"prefix":"10.1111","volume":"33","author":[{"given":"Saubhik","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra S.","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research 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