{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:52:23Z","timestamp":1761663143055,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016275","name":"Seoul National University Bundang Hospital","doi-asserted-by":"crossref","award":["02-2010-016"],"award-info":[{"award-number":["02-2010-016"]}],"id":[{"id":"10.13039\/100016275","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Coffee consumption is inversely related to the risk of cirrhosis or hepatocellular carcinoma (HCC<\/jats:styled-content>). However, the protective effect of coffee drinking against the risk of HCC<\/jats:styled-content> was not established in HBV<\/jats:styled-content>\u2010prevalent region. To elucidate the relationship between lifetime coffee consumption and the risk of HCC<\/jats:styled-content> development under the consideration of replication status of HBV<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A hospital\u2010based case\u2013control study was performed in 1364 subjects. A total of 258 HCC<\/jats:styled-content> patients, 480 health\u2010check examinees (control 1, HCE<\/jats:styled-content>) and 626 patients with chronic liver disease other than HCC<\/jats:styled-content> (control 2, CLD<\/jats:styled-content>) were interviewed on smoking, alcohol and coffee drinking using a standardized questionnaire. HBV<\/jats:styled-content> e\u2010antigen (HB<\/jats:styled-content>eAg) status and serum HBV DNA<\/jats:styled-content> levels were measured in patients infected with HBV<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>After adjustment for age, gender, obesity, DM<\/jats:styled-content>, presence of hepatitis virus (except for HCE<\/jats:styled-content>) and lifetime alcohol drinking\/smoking, a high lifetime coffee consumption (\u226520\u00a0000 cups) was an independent protective factor against HCC<\/jats:styled-content>, in each analyses using healthy and risky control groups respectively (HCE<\/jats:styled-content> group, OR<\/jats:styled-content> 0.56, 95% CI 0.33\u20130.95; CLD<\/jats:styled-content> group, OR<\/jats:styled-content> 0.55, 95% CI 0.36\u20130.85). However, the high coffee consumption did not affect the HCC<\/jats:styled-content> risk in patients with HBV<\/jats:styled-content> (OR<\/jats:styled-content> 0.64, 95% CI 0.36\u20131.14) after adjustment for HB<\/jats:styled-content>eAg status, serum HBV DNA<\/jats:styled-content> level and antiviral therapy.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A high lifetime coffee consumption was negatively associated with a HCC<\/jats:styled-content> development. However, this difference of coffee exposure with the HCC<\/jats:styled-content> group was reduced in chronic hepatitis B patients by the dominant role of viral replication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12186","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T08:37:14Z","timestamp":1365064634000},"page":"1092-1099","source":"Crossref","is-referenced-by-count":14,"title":["The effect of coffee consumption on the development of hepatocellular carcinoma in hepatitis B virus endemic area"],"prefix":"10.1111","volume":"33","author":[{"given":"Eun Sun","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sook\u2010Hyang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National 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