{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:48:16Z","timestamp":1789382896845,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Cardiac dysfunction has been described in patients with cirrhosis. Conventional echocardiographic methods are frequently unable to detect abnormalities at rest and have limitations. We aimed to evaluate cardiac function in cirrhosis patients assessing: (i) left ventricular systolic function using speckle\u2010tracking imaging; (ii) diastolic function using a tissue\u2010Doppler based algorithm and comparing it with previously proposed definition of diastolic dysfunction (<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 109 hospitalized and ambulatory patients with cirrhosis and 18 healthy controls. Detailed echocardiographic evaluation was performed including tissue\u2010Doppler and speckle\u2010tracking analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peak systolic longitudinal strain (<jats:styled-content style=\"fixed-case\">PLS<\/jats:styled-content>) was lower in patients [\u221219.99% (\u221221.88 to \u221218.71) vs \u221222.02% (\u221223.10 to \u221221.18), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003]. Ejection fraction was similar in patients and controls [64% (59\u201367) vs 61% (60\u201365), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.42)]. Based on mitral\u2010flow pattern, <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> was present in 44 patients (40.4%). Patients without <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> had higher cardiac output compared with those with <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> [6.4\u00a0L\/min (5.4\u20137.2) vs 5.6\u00a0L\/min (4.6\u20136.8), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02]. Using a tissue\u2010Doppler based definition, the prevalence of <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> was 16.5%. No differences in haemodynamic variables were found in patients with and without this definition of <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>. The agreement between the two definitions of <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> was weak (kappa\u00a0=\u00a00.24, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). Echocardiographic abnormalities in systolic and diastolic function were not different in compensated vs decompensated patients in different Child\u2010Pugh classes or cirrhosis aetiologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with cirrhosis have systolic and diastolic cardiac dysfunction at rest. Newer echocardiographic techniques may identify patients with functional impairment more accurately than conventional methods, which are more influenced by flow conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12187","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T08:37:13Z","timestamp":1365064633000},"page":"1158-1165","source":"Crossref","is-referenced-by-count":91,"title":["Systolic and diastolic dysfunction in cirrhosis: a tissue\u2010Doppler and speckle tracking echocardiography study"],"prefix":"10.1111","volume":"33","author":[{"given":"Francisco","family":"Sampaio","sequence":"first","affiliation":[{"name":"Cardiology Department Centro Hospitalar de Gaia\/Espinho Espinho Portugal"},{"name":"University of Porto Medical School Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Pimenta","sequence":"additional","affiliation":[{"name":"University of Porto Medical School Porto 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