{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:05:06Z","timestamp":1791068706796,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study evaluated the effect of statins in Primary biliary cirrhosis (<jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>) on endothelial function, anti\u2010oxidant status and vascular compliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Primary biliary cirrhosis patients with hypercholesterolaemia were randomized to receive 20\u00a0mg simvastatin or placebo in a single blind, randomized controlled trial. Body mass index, blood pressure, glucose, liver function, lipid profile, immunoglobulin levels, serological markers of endothelial function and anti\u2010oxidant status were measured as well as vascular compliance, calculated from pulse wave analysis and velocity, at recruitment and again at 3, 6, 9 and 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> patients (<jats:italic>F<\/jats:italic>\u00a0=\u00a020, mean age = 55) were randomized to simvastatin 20\u00a0mg (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) or matched placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a010). At completion of the trial, serum cholesterol levels in the simvastatin group were significantly lower compared with the placebo group (4.91\u00a0mmol\/L vs. 6.15\u00a0mmol\/L, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Low\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>) levels after 12\u00a0months were also significantly lower in the simvastatin group (2.33\u00a0mmol\/L vs. 3.53\u00a0mmol\/L, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). After 12\u00a0months of treatment, lipid hydroperoxides were lower (0.49\u00a0\u03bcmol\/L vs. 0.59\u00a0\u03bcmol\/L, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.10) while vitamin C levels were higher (80.54\u00a0\u03bcmol\/L vs. 77.40\u00a0\u03bcmol\/L, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.95) in the simvastatin group. Pulse wave velocity remained similar between treatment groups at 12\u00a0months (8.45\u00a0m\/s vs. 8.80\u00a0m\/s, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.66). Only one patient discontinued medication owing to side effects. No deterioration in liver transaminases was noted in the simvastatin group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Statin therapy in patients with <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> appears safe and effective towards overall reductions in total cholesterol and <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> levels. Our initial study suggests that simvastatin may also confer advantageous effects on endothelial function and antioxidant status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12191","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T21:06:26Z","timestamp":1367528786000},"page":"1166-1174","source":"Crossref","is-referenced-by-count":48,"title":["Randomized controlled trial assessing the effect of simvastatin in primary biliary cirrhosis"],"prefix":"10.1111","volume":"33","author":[{"given":"William J.","family":"Cash","sequence":"first","affiliation":[{"name":"Department of Hepatology (Liver Unit) Royal Victoria Hospital Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Royal Victoria Hospital Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark 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