{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:49:39Z","timestamp":1771652979573,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007771","name":"Medical University of Silesia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>In autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>), inflammation is closely related to fibrosis. Although transaminase levels are commonly used to assess hepatic inflammation, they may not relate directly to the histology. We developed a noninvasive diagnostic score as an alternative to liver biopsy to help optimize treatment for <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> and monitor disease progress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010two participants with type 1 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> who had undergone liver biopsy were included (44 in training and 38 in validation sets). Liver histology was assessed according to the histologic activity index (<jats:styled-content style=\"fixed-case\">HAI<\/jats:styled-content>; score 0\u201318) and Ishak's histologic fibrosis index (<jats:styled-content style=\"fixed-case\">HFI<\/jats:styled-content>; score 0\u20136). High inflammation was defined as <jats:styled-content style=\"fixed-case\">HAI<\/jats:styled-content>&gt;4, and advanced fibrosis was defined as <jats:styled-content style=\"fixed-case\">HFI<\/jats:styled-content>&gt;2. Routine laboratory test findings and stepwise linear regression were used to develop the best models predicting <jats:styled-content style=\"fixed-case\">HAI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HFI<\/jats:styled-content>. The best cut\u2010off value to predict high inflammation and advanced fibrosis for these formulas was then calculated based on receiver\u2010operating characteristic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cut\u2010off value for a model predicting high inflammation was \u22653.57 (<jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content>\u00a0=\u00a00.93; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.86\u20131.00), with 100% sensitivity and 85% specificity. High inflammation was confirmed with an 81% positive predictive value and excluded with a 100% negative predictive value. In the validation set, the sensitivity, specificity, positive predictive value and negative predictive values were 100, 56, 88 and 100% respectively. The diagnostic yield of the fibrosis score was unsatisfactory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The noninvasive <jats:italic>inflammatory score<\/jats:italic> based on four routine laboratory parameters discriminated patients with and without significant hepatic inflammation and may facilitate follow\u2010up of type 1 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12198","type":"journal-article","created":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T09:41:15Z","timestamp":1366364475000},"page":"1370-1377","source":"Crossref","is-referenced-by-count":19,"title":["Laboratory\u2010based scoring system for prediction of hepatic inflammatory activity in patients with autoimmune hepatitis"],"prefix":"10.1111","volume":"33","author":[{"given":"Krzysztof","family":"Gutkowski","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Hartleb","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Kacperek\u2010Hartleb","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Kajor","sequence":"additional","affiliation":[{"name":"Department of Pathomorphology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W\u0142odzimierz","family":"Mazur","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W\u0142odzimierz","family":"Zych","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medical Center for Postgraduate Education Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u017cena","family":"Walewska\u2010Zielecka","sequence":"additional","affiliation":[{"name":"Department of Public Health Faculty of Health Sciences Warsaw Medical University Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Habior","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medical Center for Postgraduate Education Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Sobolewski","sequence":"additional","affiliation":[{"name":"The Faculty of Management Rzeszow University of Technology Rzeszow 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