{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:32:01Z","timestamp":1787502721599,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The role of clinically significant portal hypertension on the prognosis of cirrhotic patients undergoing hepatic resection for hepatocellular carcinoma (\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      ) is debated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      In this study, our aim was to assess the role of clinically significant portal hypertension after hepatic resection for\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      in patients with cirrhosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We assessed the prognostic role of the presence of clinically significant portal hypertension (oesophageal\/gastric varices\/portal hypertensive gastropathy or a platelet count &lt;100\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      \/L associated with splenomegaly) in 152 patients with compensated cirrhosis who underwent hepatic resection for\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      at the Italian Liver Cancer centres. Survival rates were assessed in the whole series, in the subgroup of Child\u2010Pugh score 5 patients with uninodular\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      \u22645\u00a0cm, and in Child\u2010Pugh score 5 patients with uninodular\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      \u22642\u00a0cm and normal bilirubin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median survival was similar in patients with and without clinically significant portal hypertension (79 vs 77\u00a0months,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.686). Child\u2010Pugh score 5 was the only variable significantly associated with survival by Cox multiple regression (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.007). In Child\u2010Pugh score 5 patients with single\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      \u22645\u00a0cm or in those with single\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      \u22642\u00a0cm and normal bilirubin, there was no survival difference between patients with and without clinically significant portal hypertension (median survival: 94 vs 78\u00a0months,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.121 and &gt;100 vs 86\u00a0months,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.742).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Presence of clinically significant portal hypertension has no influence on survival of patients with well\u2010compensated cirrhosis undergoing hepatic resection for\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.12199","type":"journal-article","created":{"date-parts":[[2013,4,20]],"date-time":"2013-04-20T04:12:38Z","timestamp":1366431158000},"page":"1594-1600","source":"Crossref","is-referenced-by-count":45,"title":["Influence of clinically significant portal hypertension on survival after hepatic resection for hepatocellular carcinoma in cirrhotic patients"],"prefix":"10.1111","volume":"33","author":[{"given":"Edoardo G.","family":"Giannini","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Interna Unit\u00e0 di Gastroenterologia Universit\u00e0 di Genova Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Savarino","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Interna Unit\u00e0 di Gastroenterologia Universit\u00e0 di Genova Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Farinati","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chirurgiche e Gastroenterologiche Unit\u00e0 di Gastroenterologia Universit\u00e0 di Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ciccarese","sequence":"additional","affiliation":[{"name":"Divisione di Chirurgia Policlinico San Marco Zingonia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianludovico","family":"Rapaccini","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Medicina Interna e Gastroenterologia Universit\u00e0 Cattolica di Roma Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella Di","family":"Marco","sequence":"additional","affiliation":[{"name":"Divisione di Medicina Azienda Ospedaliera Bolognini Seriate Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Benvegn\u00f9","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Sperimentale Unit\u00e0 di Medicina Universit\u00e0 di Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Zoli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche Unit\u00e0 di Medicina Interna Alma Mater Studiorum \u2013 Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Borzio","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Unit\u00e0 di Medicina Interna ed Epatologia Ospedale 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