{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:45:34Z","timestamp":1790779534442,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Non\u2010alcoholic fatty liver disease (NAFLD<\/jats:styled-content>) is suspected to confer an increased risk for developing type 2 diabetes (DM<\/jats:styled-content>). However, only a few prospective studies evaluated NAFLD<\/jats:styled-content> as a predictor for DM<\/jats:styled-content>, most did not adjust for the full range of potential cofounders and none used an objectively quantified degree of steatosis. Our aim was to evaluate the independent role of NAFLD<\/jats:styled-content> in predicting the development of pre\u2010DM<\/jats:styled-content> in a 7\u2010year prospective follow\u2010up of healthy volunteers.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective cohort of a subsample of the Israeli National Health Survey evaluated at baseline and after 7\u00a0years by identical protocols. Metabolic parameters and ultrasonographic evidence of NAFLD<\/jats:styled-content> were evaluated in 213 subjects, without known liver disease or history of alcohol abuse. Exclusion criteria were pre\u2010DM<\/jats:styled-content> at the baseline survey. Steatosis was quantified by ultrasound with the hepato\u2010renal ultrasound index (HRI<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>The study included 141 volunteers (mean age 48.78\u00a0\u00b1\u00a09.68, 24.82% with NAFLD<\/jats:styled-content>) without pre\u2010DM<\/jats:styled-content>\/DM<\/jats:styled-content> at baseline. Both NAFLD<\/jats:styled-content> on regular US<\/jats:styled-content> (OR<\/jats:styled-content>=2.93, 1.02\u20138.41 95%CI<\/jats:styled-content>) and HRI<\/jats:styled-content> (OR<\/jats:styled-content>=7.87, 1.83\u201333.82) were independent predictors for the development of pre\u2010DM<\/jats:styled-content>, adjusting for age, gender, BMI<\/jats:styled-content>, family history of DM<\/jats:styled-content>, baseline insulin, adiponectin and glucose. Further adjustment for physical activity and dietary intake did not weaken the association. Furthermore, NAFLD<\/jats:styled-content> was a stronger predictor for pre\u2010DM<\/jats:styled-content> than the metabolic syndrome. Subjects with both NAFLD<\/jats:styled-content> and glucose \u226589 had 93.3% incidence rate of pre\u2010DM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Non\u2010alcoholic fatty liver disease is a strong and independent risk factor for pre\u2010DM<\/jats:styled-content> in the general adult population; thus, NAFLD<\/jats:styled-content> patients should be classified as a population at risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12200","type":"journal-article","created":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T09:43:23Z","timestamp":1366364603000},"page":"1406-1412","source":"Crossref","is-referenced-by-count":76,"title":["Non\u2010alcoholic fatty liver disease independently predicts prediabetes during a 7\u2010year prospective follow\u2010up"],"prefix":"10.1111","volume":"33","author":[{"given":"Shira","family":"Zelber\u2010Sagi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Tel Aviv Sourasky Medical Center Tel Aviv 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