{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:21:27Z","timestamp":1788870087495,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC-101-2314-B-002-164"],"award-info":[{"award-number":["NSC-101-2314-B-002-164"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC-101-2314-B-002-141"],"award-info":[{"award-number":["NSC-101-2314-B-002-141"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Health","award":["DOH101-TD-B-111-001"],"award-info":[{"award-number":["DOH101-TD-B-111-001"]}]},{"name":"National Clinical Trial & Research Center"},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"crossref","award":["NCTRC201208"],"award-info":[{"award-number":["NCTRC201208"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"crossref","award":["NTUHYL101.X007"],"award-info":[{"award-number":["NTUHYL101.X007"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>\n                      For patients with advanced hepatocellular carcinoma (\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      ) who have failed first\u2010line anti\u2010angiogenic therapy, there is no salvage treatment. Hepatic arterial infusion of chemotherapy (\n                      <jats:styled-content style=\"fixed-case\">HAIC<\/jats:styled-content>\n                      ) has been reported to achieve substantial treatment responses in\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      patients. We aimed to explore the feasibility of using\n                      <jats:styled-content style=\"fixed-case\">HAIC<\/jats:styled-content>\n                      as second\u2010line therapy for advanced\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed all consecutive patients who received\n                      <jats:styled-content style=\"fixed-case\">HAIC<\/jats:styled-content>\n                      for advanced\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      after failure of first\u2010line anti\u2010angiogenic therapy at a single institute. Patients received\n                      <jats:styled-content style=\"fixed-case\">HAIC<\/jats:styled-content>\n                      with 60\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      cisplatin on Day 2, and 500\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/d dose of 5\u2010fluorouracil on Days 1\u20133. The treatment was repeated every 21\u00a0days and continued until disease progression or the occurrence of intolerable toxicities. Tumour assessment was performed after every 3 cycles of\n                      <jats:styled-content style=\"fixed-case\">HAIC<\/jats:styled-content>\n                      following RECIST criteria, version 1.0.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 23 patients were included. Eleven (48%) patients had main portal vein thrombosis. Liver reserve was classified as Child\u2010Pugh A in 19 (83%) patients and B in 4 (17%) patients. No complete response was observed, although 6 (26%) patients showed partial responses. The median progression\u2010free survival was 4.4\u00a0months, and the median overall survival was 7.5\u00a0months. Common toxicities included bone marrow suppression, elevated transaminase levels, neutropenia, nausea and malaise. Only 7 (30%) patients experienced grade 3 or 4 toxicities, and no patients withdrew from the therapy because of intolerable or life\u2010threatening toxicities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">HAIC<\/jats:styled-content>\n                      is a feasible second\u2010line therapy for patients with advanced\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      who have failed anti\u2010angiogenic therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.12207","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T03:13:42Z","timestamp":1368069222000},"page":"1413-1419","source":"Crossref","is-referenced-by-count":15,"title":["A pilot study of hepatic arterial infusion of chemotherapy for patients with advanced hepatocellular carcinoma who have failed anti\u2010angiogenic therapy"],"prefix":"10.1111","volume":"33","author":[{"given":"Yu\u2010Yun","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital Taipei Taiwan"},{"name":"Graduate Institute of Oncology National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Chin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Chieh","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology Far Eastern Memorial Hospital New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Wen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital Taipei Taiwan"},{"name":"Graduate Institute of Oncology National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Hung","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital Taipei Taiwan"},{"name":"Graduate 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intra\u2010arterial cetuximab in combination with 5\u2010fluorouracil and cisplatin as salvage treatment for sorafenib\u2010refractory hepatocellular carcinoma","volume":"31","author":"Poggi G","year":"2011","journal-title":"Anticancer Res"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1991"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji315"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0281"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31818ddfc6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320377"},{"key":"e_1_2_6_26_1","unstructured":"Ministry of Health Labour and Welfare Japan.Comparing efficacy of sorafenib versus sorafenib in combination with low\u2010dose FP in patients with advanced HCC. 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