{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:18:33Z","timestamp":1790054313300,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T00:00:00Z","timestamp":1371600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea","award":["A102065"],"award-info":[{"award-number":["A102065"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In experimental models, bone marrow\u2010derived mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s) have the capacity to differentiate into hepatocytes and exhibit antifibrotic effects. However, there have been no studies in humans with alcoholic cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to elucidate the antifibrotic effect of <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s in patients with alcoholic cirrhosis, as a phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve patients (11 males, 1 female) with baseline biopsy\u2010proven alcoholic cirrhosis who had been alcohol free for at least 6\u00a0months were enrolled. <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s were isolated from each patient's <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> and amplified for 1\u00a0month, and 5\u00a0\u00d7\u00a010<jats:sup>7<\/jats:sup> cells were then injected twice, at weeks 4 and 8, through the hepatic artery. One patient was withdrawn because of ingestion of alcohol. Finally, 11 patients completed the follow\u2010up biopsy and laboratory tests at 12\u00a0weeks after the second injection. The primary outcome was improvement in the patients\u2019 histological features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the Laennec fibrosis system, histological improvement was observed in 6 of 11 patients (54.5%). The Child\u2010Pugh score improved in ten patients (90.9%) and the levels of transforming growth factor\u2010\u03b21, type 1 collagen and \u03b1\u2010smooth muscle actin significantly decreased (as assessed by real\u2010time reverse transcriptase polymerase chain reaction) after <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s therapy (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). No significant complications or side effects were observed during this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bone marrow\u2010derived mesenchymal stem cells therapy in alcoholic cirrhosis induces a histological and quantitative improvement of hepatic fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12218","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T16:24:51Z","timestamp":1368635091000},"page":"33-41","source":"Crossref","is-referenced-by-count":164,"title":["Histological improvement following administration of autologous bone marrow\u2010derived mesenchymal stem cells for alcoholic cirrhosis: a pilot study"],"prefix":"10.1111","volume":"34","author":[{"given":"Yoon Ok","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju Korea"},{"name":"Department of Cell Therapy and Tissue Engineering Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Koo","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju Korea"},{"name":"Department of Cell Therapy and Tissue Engineering Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju Korea"},{"name":"Department of Cell Therapy and Tissue Engineering Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Woo","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Cell Therapy and Tissue Engineering Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mee Yon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Ra","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Soo Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Ok","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hee","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of medical statistics Yonsei University Wonju College of Medicine  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Man","family":"Kim","sequence":"additional","affiliation":[{"name":"FCB\u2010Pharmicell Co., Ltd.  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