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Previous studies showed that functional polymorphisms in the <jats:italic><jats:styled-content style=\"fixed-case\">MTTP<\/jats:styled-content><\/jats:italic> gene correspond to lower <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> levels and protect against other traits of the metabolic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Here, we aimed to investigate whethe<jats:italic>r <jats:styled-content style=\"fixed-case\">MTTP<\/jats:styled-content><\/jats:italic> single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) and their predicted haplotypes of linkage disequilibrium blocks contribute to non\u2010alcoholic fatty liver disease (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>) susceptibility in a Han Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven tag <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in the <jats:italic><jats:styled-content style=\"fixed-case\">MTTP<\/jats:styled-content><\/jats:italic> gene were selected and genotyped in a frequency\u2010matched case\u2013control study in a population from Fuzhou City, China. We enrolled 580 patients with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> and 580 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the multivariate logistic regression analysis, the rs1800804 (\u2010164 T\/C) was associated with an increased risk of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>, while the rs1057613 A\/G and rs3805335 C\/T <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s were associated with a decreased risk of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>. The cumulative effect of the rs1800804 (\u2010164 T\/C), rs1057613 and rs3805335 was estimated, and a significant increased trend in the risk of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> with increasing genetic risk score was observed (adjusted <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u00a0=\u00a00.014). Furthermore, the results of haplotype analysis suggested that the haplotype <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> in block 1 containing the \u2010164 C allele was associated with an increased risk of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>, while haplotype <jats:styled-content style=\"fixed-case\">TGTTC<\/jats:styled-content> in block 2 was associated with a decreased risk of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data show that <jats:italic><jats:styled-content style=\"fixed-case\">MTTP<\/jats:styled-content><\/jats:italic> genetic polymorphisms influence the susceptibility to developing <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> independently or jointly in the Han Chinese population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12220","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T16:26:47Z","timestamp":1368635207000},"page":"118-128","source":"Crossref","is-referenced-by-count":39,"title":["<i><scp>MTTP<\/scp><\/i> polymorphisms and susceptibility to non\u2010alcoholic fatty liver disease in a Han Chinese population"],"prefix":"10.1111","volume":"34","author":[{"given":"Xian E.","family":"Peng","sequence":"first","affiliation":[{"name":"Key Laboratory of Ministry of Education for Gastrointestinal Cancer School of Basic Medical Sciences Fujian Medical University Fuzhou China"},{"name":"Department of Epidemiology and Health Statistics School of Public Health Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun L.","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ministry of Education for Gastrointestinal Cancer School of Basic 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