{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:16:10Z","timestamp":1783430170647,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T00:00:00Z","timestamp":1372204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100016298","name":"ERA-EDTA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100016298","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Konya University Scientific Research Projects Fund","award":["11102033"],"award-info":[{"award-number":["11102033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Hepatorenal syndrome (<jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>) is a severe complication of cirrhosis which is characterized by renal dysfunction and associated with poor survival. Neutrophil gelatinase\u2010associated lipocalin (<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>) is a troponin\u2010like biomarker for human acute kidney injury.<\/jats:p><jats:p>We aimed to investigate levels of plasma and urine <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content> and predictive ability of these markers for all\u2010cause mortality, in <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>, stable cirrhosis and control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 64 patients with cirrhosis (8 patients with type 1 <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>, 22 with type 2 <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>, and 34 without <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>) and 23 control subjects were included in the study.<\/jats:p><jats:p>Blood and urine samples were measured with Human <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> sandwich <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Patients were followed up prospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with type 1 and type 2 <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content> had significantly higher plasma and urine <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> levels compared with stable cirrhosis and control subjects. Cox regression analysis showed that plasma <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>\u2010Na scores were independent predictors of mortality. <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>\u2010curve analysis showed that the plot of the plasma <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>, urine <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MELD<\/jats:styled-content>\u2010Na and Child\u2010Turcot\u2010Pugh score could predict all\u2010cause mortality in cirrhotic patients' area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> 0.819, 0.686, 0.807 and 0.795 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> could predict mortality in patients with <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content> independent of other commonly used risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12232","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T16:14:51Z","timestamp":1369239291000},"page":"49-57","source":"Crossref","is-referenced-by-count":43,"title":["Neutrophil gelatinase\u2010associated lipocalin in prediction of mortality in patients with hepatorenal syndrome: a prospective observational study"],"prefix":"10.1111","volume":"34","author":[{"given":"Gokhan","family":"Gungor","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Meram School of Medicine Konya University Meram Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Ataseven","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Meram School of Medicine Konya University Meram Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Demir","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Meram School of Medicine Konya University Meram Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalcin","family":"Solak","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Meram School of Medicine Konya University Meram Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abduzhappar","family":"Gaipov","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Meram School of Medicine Konya University Meram Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Biyik","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Meram School of Medicine Konya University Meram Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahadir","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Biochemical Laboratory Selcuklu School of Medicine Selcuk University Selcuklu Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilker","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Meram School of Medicine Konya University Meram Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysel","family":"Kiyici","sequence":"additional","affiliation":[{"name":"Department of Biochemical Laboratory Selcuklu School of Medicine Selcuk University Selcuklu Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem O.","family":"Cakir","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine 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