{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:16:41Z","timestamp":1767212201899,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T00:00:00Z","timestamp":1375056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei-Veterans General Hospital","doi-asserted-by":"crossref","award":["VGH97E2-014"],"award-info":[{"award-number":["VGH97E2-014"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Promoting Academic Excellence of Universities Genome-Based Biomedical Research","award":["89-B-FA22-2-4"],"award-info":[{"award-number":["89-B-FA22-2-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Animal model suitable for studying herb\u2010induced experimental autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>) remains a challenging problem. A medicinal herb containing <jats:italic>Scutellaria baicalensis<\/jats:italic> Georgi (Sb) and <jats:italic>Bupleurum chinense <\/jats:italic><jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> (Bc) has been sporadically reported to be related to liver fibrosis. The aim of this study was to investigate the effects of Sb and Bc on experimental <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6J mice received intraperitoneal injection of Sb and\/or Bc herbal extracts (1\u00a0mg\/kg) for 4 or 8\u00a0weeks. Serum samples were collected to analyse serum transferase (<jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ALT<\/jats:styled-content>), creatinine, markers for <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> and hepatic cytokine levels such as <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10 and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21. Peripheral mononuclear cell (<jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>) gene expression profiles were analysed to show their effects on immune system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that Sb or Bc treatment increased serum <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ALT<\/jats:styled-content>, IgG and <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content> levels. Prominent necroinflammatory changes were demonstrated in the livers of Sb\u2010 or Bc\u2010treated mice while the decrease in <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 and elevation of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10 and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21 levels in liver tissues. Furthermore, the <jats:styled-content style=\"fixed-case\">PMBC<\/jats:styled-content> gene expression profile suggested that Sb or Bc treatment could modulate immune responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that the presence of <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> in Sb\u2010 or Bc\u2010treated mice and C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6J strain mice is a reliable animal model for studying herb\u2010induced <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>\u2010like hepatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12266","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T08:05:41Z","timestamp":1372665941000},"page":"583-593","source":"Crossref","is-referenced-by-count":10,"title":["Herb\u2010induced autoimmune\u2010like hepatitis in C57<scp>BL<\/scp>\/6J mice"],"prefix":"10.1111","volume":"34","author":[{"given":"Jir\u2010You","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Traditional Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Orthopaedics Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Yin","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Medicine The School of Chinese Medicine for Post Baccalaureate I\u2010Shou University (Yancho Campus) Kaohsiung Taiwan"},{"name":"Department of Chinese Medicine E\u2010DA Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Jung","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Chi","family":"Chang","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen\u2010Hwey","family":"Chiu","sequence":"additional","affiliation":[{"name":"Institute of Traditional Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Division of General Surgery Department of Surgery Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Division of General Surgery Department of Surgery Cheng\u2010Hsiung General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Shone","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Experimental Surgery Department of Surgery Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ming","family":"Shyr","sequence":"additional","affiliation":[{"name":"Division of General Surgery Department of Surgery Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-011-0236-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.11.030"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hch072"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1024\/0369-8394.91.34.1339"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03165.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2011.00844.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199906)42:6<1071::AID-ANR1>3.0.CO;2-8"},{"key":"e_1_2_8_9_1","first-page":"237","article-title":"Analysis of HLA\u2010class\u2010II\u2010encoded antigen\u2010processing genes TAP1 and TAP2 in primary biliary cirrhosis","volume":"87","author":"Gregory WL","year":"1994","journal-title":"Q J Med"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.2.150"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80232-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.08.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23792"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt.13.5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80492-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(96)03594-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2003.00843.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02864.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02349.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.01.029"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021844"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)82333-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i2.119"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2012.12.001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.10.6413"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700246"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02212712"},{"key":"e_1_2_8_28_1","first-page":"703","article-title":"Autoimmune hepatitis triggered by administration of an herbal medicine","volume":"92","author":"Kamiyama T","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_8_29_1","first-page":"221","article-title":"Gene expression profiling predicts liver responses to a herbal remedy after partial hepatectomy in mice","volume":"16","author":"Wang JY","year":"2005","journal-title":"Int J Mol Med"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020623100410"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01698.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1035"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0170-7"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21711"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000155548.91524.6e"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-2017-z"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2005.11.001"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3306"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35705"},{"key":"e_1_2_8_41_1","first-page":"1780","article-title":"Serum level of transforming growth factor\u2010beta1 (TGF\u2010beta1) and the expression of TGF\u2010beta receptor type II in peripheral blood mononuclear cells in patients with autoimmune hepatitis","volume":"51","author":"Sakaguchi K","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)01913-6"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12266","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.12266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:02:34Z","timestamp":1695567754000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.12266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,29]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/liv.12266"],"URL":"https:\/\/doi.org\/10.1111\/liv.12266","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"type":"print","value":"1478-3223"},{"type":"electronic","value":"1478-3231"}],"subject":[],"published":{"date-parts":[[2013,7,29]]}}}