{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:32:28Z","timestamp":1774571548630,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,15]],"date-time":"2013-08-15T00:00:00Z","timestamp":1376524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Anaesthesia and Pain Management Special Purpose Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Volatile anaesthetic drug\u2010induced liver injury can range from asymptomatic alanine transaminase elevations to fatal hepatic necrosis. There is very limited research regarding hepatotoxicity of modern volatile anaesthetic agents. The aim of this study was to determine how common liver injury consistent with volatile anaesthetic hepatitis is, following exposure to isoflurane, desflurane and sevoflurane; and to propose risk factors for its development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following ethics approval, we conducted a retrospective audit of adult trauma patients with abnormal liver biochemistry following volatile anaesthesia during <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 1 to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 31, 2009. The data collected included patient demographics, volatile anaesthetic administration, concurrent medication, perioperative liver biochemistry results and comorbidities. The Council for International Organisations of Medical Sciences\/Roussel Uclaf Causality Assessment Method scoring system was used to group cases according to the likelihood of volatile anaesthetic being the causative agent of drug\u2010induced hepatotoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven (3%) of 1556 patients had abnormal post\u2010operative liver biochemistry potentially attributable to volatile anaesthetic. Of the 47, 12 patients (26%) had peak alanine transaminase levels greater than 200\u00a0U\/L. No significant predictors of volatile anaesthetic drug\u2010induced liver injury following isoflurane, desflurane or sevoflurane anaesthesia could be identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Volatile anaesthetic drug\u2010induced liver injury in adult trauma patients may be significantly more common than previously noted. This study suggests that about a quarter of patients with volatile anaesthetic drug\u2010induced liver injury develop significant liver injury. Further prospective studies are required to define risk factors and clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12278","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T02:11:26Z","timestamp":1374718286000},"page":"576-582","source":"Crossref","is-referenced-by-count":25,"title":["Drug\u2010induced hepatotoxicity: incidence of abnormal liver function tests consistent with volatile anaesthetic hepatitis in trauma patients"],"prefix":"10.1111","volume":"34","author":[{"given":"Jonathan","family":"Lin","sequence":"first","affiliation":[{"name":"The University of Melbourne Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management The Royal Melbourne Hospital Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad","family":"Hockey","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management The Royal Melbourne Hospital Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Di Lernia","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management The Royal Melbourne Hospital Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Gorelik","sequence":"additional","affiliation":[{"name":"Melbourne EpiCentre The Royal Melbourne Hospital Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny","family":"Liew","sequence":"additional","affiliation":[{"name":"Melbourne EpiCentre The Royal Melbourne Hospital Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Nicoll","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The Royal Melbourne Hospital Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/bean.2002.0265"},{"key":"e_1_2_6_3_1","volume-title":"The National Halothane Study. 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