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The association between early\u2010life malnutrition and hepatic redox balance in diet\u2010induced insulin resistance is unknown. We investigated <jats:styled-content style=\"fixed-case\">TAU<\/jats:styled-content> supplementation effects upon liver redox state and insulin signalling in obese protein malnourished mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Weaned male C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\u20106 mice were fed a control (14% protein \u2013 C) or a protein\u2010restricted diet (6% protein \u2013 R) for 6\u00a0weeks. Afterwards, mice received a high\u2010fat diet (34% fat \u2013 <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>) for 8\u00a0weeks (<jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content> \u2013 <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>). Half of the <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>\u2010mice were supplemented with <jats:styled-content style=\"fixed-case\">TAU<\/jats:styled-content> (5%) throughout the treatment (<jats:styled-content style=\"fixed-case\">CHT<\/jats:styled-content> \u2013 <jats:styled-content style=\"fixed-case\">RHT<\/jats:styled-content>). Body and tissues' weight, respiratory quotient (<jats:styled-content style=\"fixed-case\">RQ<\/jats:styled-content>), glucose tolerance and insulin sensitivity, hepatic oxidant and antioxidant markers and insulin cascade proteins were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Protein restriction leads to typical features whereas <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content> was able to induce a catch\u2010up growth in <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>\u2010groups showed higher energy intake and adiposity, lower energy expenditure and altered <jats:styled-content style=\"fixed-case\">RQ<\/jats:styled-content>. Glucose tolerance and insulin sensitivity were impaired in <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>\u2010groups and <jats:styled-content style=\"fixed-case\">TAU<\/jats:styled-content> attenuated these effects. <jats:styled-content style=\"fixed-case\"><jats:roman>H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> content was increased in <jats:styled-content style=\"fixed-case\">CHT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RHT<\/jats:styled-content> despite no differences in antioxidant enzymes and <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> concentration. <jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content> phosphorylation were significantly increased in <jats:styled-content style=\"fixed-case\">CHT<\/jats:styled-content> but not in <jats:styled-content style=\"fixed-case\">RHT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data provide evidence for an association between <jats:styled-content style=\"fixed-case\">TAU<\/jats:styled-content>\u2010induced improved glycaemic control because of <jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content> inactivation and higher <jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content> phosphorylation. These effects seem to be related with altered hepatic redox balance in obese mice, and this effect is impaired by protein malnutrition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12291","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T09:02:15Z","timestamp":1375261335000},"page":"771-783","source":"Crossref","is-referenced-by-count":26,"title":["Taurine\u2010induced insulin signalling improvement of obese malnourished mice is associated with redox balance and protein phosphatases activity modulation"],"prefix":"10.1111","volume":"34","author":[{"given":"Ana P.","family":"Cappelli","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology Institute of Biology State University of Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio C.","family":"Zoppi","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Institute of 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