{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:24:16Z","timestamp":1777523056926,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Cytochrome c (<jats:styled-content style=\"fixed-case\">CYC<\/jats:styled-content>) and M30\u2010neoepitope of cytokeratin\u201018 (M30\u2010<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>18) are involved at different levels in apoptotic pathways. We aimed to evaluate an association between serum <jats:styled-content style=\"fixed-case\">CYC<\/jats:styled-content>, M30\u2010<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>18 and disease activity as well response to therapy in chronic hepatitis C (<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content> patients were enrolled in this study. Forty five of them completed pegylated interferon plus ribavirin therapy. Histopathological evaluation of hepatic inflammatory activity and fibrosis, as well as blood liver function tests, was performed. Serum concentrations of M30\u2010<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>18 and <jats:styled-content style=\"fixed-case\">CYC<\/jats:styled-content> were measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median serum concentration of M30\u2010CK18 was higher in CHC patients [283 U\/L] vs. control [113 U\/L] (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0003) and was associated with inflammatory activity and liver fibrosis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Serum M30\u2010CK18 positively correlated with serum activity of ALT and GGT. CYC was not detected in sera of control group, whereas in CHC, 41.43% patients had detectable CYC in serum samples [0.60\u00a0ng\/<jats:styled-content style=\"fixed-case\">ml<\/jats:styled-content>]. Detectable baseline serum CYC had been negatively associated with sustained virological response (SVR). In patients with detectable CYC, SVR rate was 20% vs. 60% in patients with undetectable CYC (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated serum M30\u2010<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>18, as an indicator of enhanced apoptosis of hepatocytes, parallels active hepatic inflammation and fibrosis but also biochemical activity in CHC; thus, it may serve as a comprehensive non\u2010invasive marker of disease activity. On the other hand, detection of serum CYC at baseline may be negatively associated with treatment response to pegylated interferon plus ribavirin in CHC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12297","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T14:08:43Z","timestamp":1375452523000},"page":"544-550","source":"Crossref","is-referenced-by-count":28,"title":["Serum cytochrome c and m30\u2010neoepitope of cytokeratin\u201018 in chronic hepatitis C"],"prefix":"10.1111","volume":"34","author":[{"given":"Anna","family":"Parfieniuk\u2010Kowerda","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bialystok Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz W.","family":"Lapinski","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bialystok Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Rogalska\u2010Plonska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bialystok Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Swiderska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bialystok Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anatol","family":"Panasiuk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bialystok Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Jaroszewicz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bialystok Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Flisiak","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bialystok Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.07.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203249"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7878464"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1991.tb00822.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.13.7557017"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00370-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.051"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i36.4865"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02159.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01592.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2012.04.006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-009-9061-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01387.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199904)187:5<567::AID-PATH288>3.0.CO;2-J"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.02.019"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.06.032"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023672805949"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00865-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90084-O"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2003.01171.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2008.01033.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111350200"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.4.2152-2157.2004"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.11.017"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1517-4"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(05)80078-2"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20411"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21186"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2006.12.010"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21699"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01546.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053519"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0959-9673.2005.00411.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20180"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-14"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(01)02124-9"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-07-2136"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12297","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.12297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:02:03Z","timestamp":1695567723000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.12297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,28]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/liv.12297"],"URL":"https:\/\/doi.org\/10.1111\/liv.12297","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,28]]}}}