{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:25:54Z","timestamp":1784309154162,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T00:00:00Z","timestamp":1381708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Non\u2010alcoholic fatty liver disease (NAFLD<\/jats:styled-content>) is associated with increased cardiovascular disease (CVD<\/jats:styled-content>) risk. Non\u2010high\u2010density lipoprotein cholesterol (non\u2010HDL<\/jats:styled-content>\u2010C), i.e. total cholesterol minus HDL<\/jats:styled-content>, is a well\u2010established risk factor for CVD<\/jats:styled-content>; however, its association with NAFLD<\/jats:styled-content> development has not been established. Our aim was to test whether non\u2010HDL<\/jats:styled-content>\u2010C is an independent predictor of new onset of NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective cohort study of 213 subjects from the general population, without liver disease, was studied. Evaluation of medical history, dietary and physical activity habits, fasting blood tests and ultrasonographic evidence of NAFLD<\/jats:styled-content> was performed at baseline and after a 7\u2010year follow\u2010up by identical protocols.<\/jats:p><\/jats:sec>Results<\/jats:title>From 147 patients that did not have NAFLD<\/jats:styled-content> at baseline, 28 (19%) developed NAFLD<\/jats:styled-content> at the 7\u2010year follow\u2010up. The baseline levels of non\u2010HDL<\/jats:styled-content>\u2010C were higher among subjects who developed NAFLD<\/jats:styled-content> (179.5\u00a0\u00b1\u00a037.1 vs. 157.3\u00a0\u00b1\u00a035.1\u00a0mg\/dl, P<\/jats:italic>\u00a0=\u00a00.003). Non\u2010HDL<\/jats:styled-content>\u2010C independently predicted new onset of NAFLD<\/jats:styled-content> adjusting for age, gender, BMI<\/jats:styled-content> or waist circumference, lifestyle and serum insulin (OR<\/jats:styled-content>\u00a0=\u00a01.02 for every mg\/dl increment, 1.01\u20131.04 95% CI<\/jats:styled-content>, P<\/jats:italic>\u00a0=\u00a00.008). Non\u2010HDL<\/jats:styled-content>\u2010C was a stronger predictor for NAFLD<\/jats:styled-content> than total cholesterol, low\u2010density lipoprotein cholesterol, triglycerides and HDL<\/jats:styled-content>. No patients with non\u2010HDL<\/jats:styled-content>\u2010C\u00a0<\u00a0130\u00a0mg\/dl developed NAFLD<\/jats:styled-content>, whereas 20.8% of those with values between 130 to 160 and 24.6% of those with values >160\u00a0mg\/dl developed NAFLD<\/jats:styled-content> (P<\/jats:italic> for trend\u00a0= 0.015).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Non\u2010HDL<\/jats:styled-content>\u2010C is an independent predictor for NAFLD<\/jats:styled-content> and a stronger predictor than other lipoproteins. This association may stem from the combined hepato\u2010toxic effect of non\u2010HDL<\/jats:styled-content>\u2010C and may explain the association between NAFLD<\/jats:styled-content> and CVD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12318","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T11:51:15Z","timestamp":1378900275000},"source":"Crossref","is-referenced-by-count":63,"title":["Non\u2010high\u2010density lipoprotein cholesterol independently predicts new onset of non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"34","author":[{"given":"Shira","family":"Zelber\u2010Sagi","sequence":"first","affiliation":[{"name":"Department Gastroenterology Tel\u2010Aviv Medical Center Tel\u2010Aviv Israel"},{"name":"School of Public Health Faculty of Social Welfare and Health Sciences University of Haifa Haifa 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