{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:20:24Z","timestamp":1762323624830,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81160162"],"award-info":[{"award-number":["81160162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Projects in the National Science & Technology Pillar Program","award":["2012ZX10001003-003-019"],"award-info":[{"award-number":["2012ZX10001003-003-019"]}]},{"DOI":"10.13039\/501100007301","name":"Kunming University of Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007301","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Acetaminophen (<jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>) is widely used as an antipyretic agent which is safe at therapeutic doses. However, overdose of <jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content> induces fatal and non\u2010fatal hepatic necroses. The chemical reactive metabolites of <jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content> initiate toxicity and inflammatory response within the liver and lead to acute liver failure. However, the mechanism underlying <jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>\u2010induced liver injury is unknown. Thioredoxin\u20101 (<jats:styled-content style=\"fixed-case\">TRX<\/jats:styled-content>\u20101) is an important redox regulator, which plays roles in resisting oxidative stress, regulating inflammation and inhibiting apoptosis. Panaxatriol saponin (<jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content>) is one of the biologically active fractions of Panax notoginseng which is a traditional Chinese medicine. The aim of this study was to investigate the mechanism on <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content> protecting liver from <jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content> hepatotoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mice were divided into three groups, control group, <jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content> group and <jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content> combined with <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content> group. Alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) and tumour necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) were detected by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">TRX<\/jats:styled-content>\u20101 and pro\u2010caspase\u201012 were examined by Western blotting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content> inhibited the levels of <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 by <jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>. Pretreatment with <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content> ameliorated liver injury induced by <jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>. The decrease in <jats:styled-content style=\"fixed-case\">TRX<\/jats:styled-content>\u20101 expression was restored by <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content>, as well as decreased pro\u2010caspase\u201012 expression was inhibited by <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content>. These data suggest that <jats:styled-content style=\"fixed-case\">PTS<\/jats:styled-content> has roles in suppressing the hepatotoxicity by <jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Panaxatriol saponin ameliorated liver injury by <jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content> through restoring the expression <jats:styled-content style=\"fixed-case\">TRX<\/jats:styled-content>\u20101 and inhibiting pro\u2010caspase\u201012 decrease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12329","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T11:51:35Z","timestamp":1378900295000},"page":"1068-1073","source":"Crossref","is-referenced-by-count":19,"title":["Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin\u20101 and pro\u2010caspase\u201012"],"prefix":"10.1111","volume":"34","author":[{"given":"Shengdong","family":"Wang","sequence":"first","affiliation":[{"name":"Faculty of Environmental Science and Engineering Kunming University of Science and Technology Kunming China"},{"name":"Department of Science and Education Section the seventh People's Hospital of Hangzhou Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Faculty Kunming University of Science and Technology Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fucheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Medical Faculty Kunming University of Science and Technology Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodan","family":"Tang","sequence":"additional","affiliation":[{"name":"The first People's Hospital of Yunnan Province Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Faculty Kunming University of Science and Technology Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Hu","sequence":"additional","affiliation":[{"name":"Medical Faculty Kunming University of Science and Technology Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Bai","sequence":"additional","affiliation":[{"name":"Medical Faculty Kunming University of Science and Technology Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.06.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-00663-0_12"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20948"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02262.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20792"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh151"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfg220"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.10.029"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2006.11.021"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2010.01.029"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.03.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.29"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(94)90038-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12550-012-0128-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.4049\/jimmunol.158.7.3108","article-title":"Adult T cell leukemia (ATL)\u2010derived factor\/human thioredoxin prevents apoptosis of lymphoid cells induced by L\u2010cystine and glutathione depletion: possible involvement of thiol\u2010mediated redox regulation in apoptosis caused by pro\u2010oxidant state","volume":"158","author":"Iwata S","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.1513"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.58.8.0001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.10.023"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.10.017"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.04.010"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.10.023"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0403152"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(01)00284-3"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201210772"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029712"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22833"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711795590039"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401080"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3628"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0046com"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/019262339602400206"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2011.11.014"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02501.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(03)00239-X"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4650"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043456098"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.338"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1891"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.06.056"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12329","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.12329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:13:56Z","timestamp":1695474836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.12329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/liv.12329"],"URL":"https:\/\/doi.org\/10.1111\/liv.12329","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"type":"print","value":"1478-3223"},{"type":"electronic","value":"1478-3231"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}