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The aims of this study were to discover new genetic variants associated with this trait and to replicate some associations formerly reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred and thirty\u2010seven <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> carriers with available data about liver fibrosis status, who initiated treatment with pegylated interferon plus ribavirin, were included. Of them, 77 (22.85%) were cirrhotic. One hundred and forty\u2010four <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s from 40 genes related to cholesterol metabolism\/transport, sustained viral response to <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> therapy, liver fibrosis, or immune response, were genotyped in all samples. Plink software was used to perform univariate association analyses. The results obtained were adjusted by other parameters related to cirrhosis using multivariate logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only the <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> rs12104272, linked to <jats:italic><jats:styled-content style=\"fixed-case\">RRAS<\/jats:styled-content><\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">SCAF<\/jats:styled-content>1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>3<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2L12<\/jats:italic> genes, was associated with cirrhosis. It was observed a higher proportion of rs12104272 A allele carriers in the non\u2010cirrhotic group (60.63%) than in the cirrhotic group (38.15%) (adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.36, 95% CI\u00a0=\u00a00.180\u20100.746, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). This effect was stronger in the background of rs12979860 <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> genotype of <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>28B<\/jats:italic> (adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.069, 95% CI\u00a0=\u00a00.014\u20130.349, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rs12104272 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> could have clinical value to select those individuals at lower risk for cirrhosis development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12330","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:03:58Z","timestamp":1381539838000},"page":"558-566","source":"Crossref","is-referenced-by-count":8,"title":["A polymorphism linked to <i><scp>RRAS<\/scp><\/i>,<i><scp>SCAF<\/scp>1<\/i>,<i><scp>IRF<\/scp>3<\/i> and <i><scp>BCL<\/scp>2L12<\/i> genes is associated with cirrhosis in hepatitis C virus carriers"],"prefix":"10.1111","volume":"34","author":[{"given":"Luis M.","family":"Real","sequence":"first","affiliation":[{"name":"Unidad de Enfermedades Infecciosas y Microbiolog\u00eda Hospital Universitario de Valme Sevilla Spain"},{"name":"Instituto de Biomedicina de Sevilla (IBIS) Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Caruz","sequence":"additional","affiliation":[{"name":"Unidad de Inmunogen\u00e9tica Universidad de Ja\u00e9n Ja\u00e9n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Rivero\u2010Juarez","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas Hospital Universitario Reina Sof\u00eda C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de 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