{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:20:11Z","timestamp":1778682011215,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30901444"],"award-info":[{"award-number":["30901444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Prognostic factors and adjuvant therapy of intrahepatic cholangiocarcinoma (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>) after curative resection were not clear. We aim to analyse prognostic factors after curative resection and evaluate adjuvant therapy and survival based on the new staging system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 283 patients who underwent surgical exploration for <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> was performed. Staging was performed according to the 7th edition <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content> staging manual. Univariate and multivariate analyses were used to evaluate independent prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The difference for <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> at different <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> stages after R0 resection was significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Despite regional lymph node metastasis, tumour number and vascular invasion, serum <jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content> level was also an independent prognostic factor for <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> of patients after R0 resection. The incidence of biliary and vascular invasion was significantly higher in high <jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content> group than in normal <jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content> group. Factors predictive of recurrence were multiple tumours and regional lymph node metastasis. After R0 resection, adjuvant <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content> not only did not improve the <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> of patients at <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> stage I (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.508), but significantly promoted recurrence of these patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). Only patients at <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> III<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> benefited from adjuvant <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content> for longer survival, while the recurrence rates were not affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The new staging system can predict the survival of <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> patients after R0 resection. High <jats:styled-content style=\"fixed-case\">GGT<\/jats:styled-content> level may be suggestive of biliary and vascular invasion and was an independent risk factor for <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> after R0 resection. Adjuvant <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content> may be indicated only for patients at advanced stages for better survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12364","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T13:21:24Z","timestamp":1382016084000},"page":"953-960","source":"Crossref","is-referenced-by-count":54,"title":["Staging, prognostic factors and adjuvant therapy of intrahepatic cholangiocarcinoma after curative resection"],"prefix":"10.1111","volume":"34","author":[{"given":"Tao","family":"Li","sequence":"first","affiliation":[{"name":"Department of General Surgery Qilu Hospital Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lun\u2010Xiu","family":"Qin","sequence":"additional","affiliation":[{"name":"Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai 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