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The objective of this study was to determine the frequency and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> and clinical associations of autoantibodies in Alaska Native people with autoimmune hepatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Alaska Native individuals with autoimmune hepatitis were recruited in clinics conducted statewide. Sera were tested for the presence of autoantibodies described in either autoimmune hepatitis or rheumatic disease. Associations between autoantibodies and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alleles and clinical features were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010one patients were included. At the study visit, 34 patients (47.9%) had antibodies to double\u2010stranded <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> by immunofluorescence; 27 (38.0%) had anti\u2010neutrophil cytoplasmic antibodies; and 11 (15.5%) had anti\u2010Ro antibodies. Only one person had antibodies against soluble liver antigen, and in that person, anti\u2010Ro was absent. Associations were found between autoantibodies and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alleles, including positive associations between <jats:styled-content style=\"fixed-case\">HLA DR<\/jats:styled-content>3 and anti\u2010double\u2010stranded <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> antibodies and between <jats:styled-content style=\"fixed-case\">HLA DR<\/jats:styled-content>14 and antineutrophil cytoplasmic antibodies. There was no association between autoantibodies and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As in other populations, the prevalence of anti\u2010double\u2010stranded <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> antibodies and antineutrophil cytoplasmic antibodies is high in Alaska Native people with autoimmune hepatitis. In contrast to data from other populations, there is a lower prevalence of anti\u2010soluble liver antigen and a lack of association between anti\u2010Ro and anti\u2010soluble liver antigen. In addition, the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> profile and associations with autoantibodies are unique. No clear prognostic implications of autoantibodies have emerged in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12372","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T20:43:39Z","timestamp":1383684219000},"page":"1241-1249","source":"Crossref","is-referenced-by-count":7,"title":["Autoimmune hepatitis in the Alaska Native population: autoantibody profile and <scp>HLA<\/scp> associations"],"prefix":"10.1111","volume":"34","author":[{"given":"Elizabeth D.","family":"Ferucci","sequence":"first","affiliation":[{"name":"Division of Community Health Services Liver Disease and Hepatitis Program Alaska Native Tribal Health Consortium Anchorage AK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy L.","family":"Choromanski","sequence":"additional","affiliation":[{"name":"Division of Community Health Services Liver Disease and Hepatitis Program Alaska Native Tribal Health Consortium Anchorage AK 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