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We have evaluated the effects of <jats:italic>Bifidobacterium pseudocatenulatum <\/jats:italic><jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content>7765 on bacterial translocation and the liver status in experimental cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals &amp; Methods<\/jats:title><jats:p>Liver damage was induced in Balb\/c mice by weight\u2010controlled oral administration of carbon tetrachloride. Laparotomies were performed at week 12. One week prior to laparotomy, animals received <jats:italic>B. pseudocatenulatum <\/jats:italic><jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content>7765 (10<jats:sup>9<\/jats:sup>cfu\/daily) or placebo intragastrically. All animals received <jats:italic>Escherichia coli<\/jats:italic> (10<jats:sup>7<\/jats:sup>cfu\/single dose) intragastrically 24 hours before laparotomy. A group of na\u00efve non\u2010treated animals was included as control. Liver tissue specimens, mesenteric lymph nodes, intestinal content and blood were collected. Liver histology, profibrogenic genes expression, bacterial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> translocation, serum endotoxaemia and liver cytokine levels were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Bifidobacterium pseudocatenulatum <\/jats:italic><jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content>7765 showed no significant effect on structural liver damage, as determined by histological evaluation, alpha\u2010smooth muscle actin distribution, profibrogenic gene expression levels, total hydroxyproline levels and malon dialdehyde production compared with mice receiving placebo. Interestingly, bacterial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> translocation and serum endotoxin levels were significantly decreased in mice receiving the <jats:italic>Bifidobacterium<\/jats:italic> strain compared with placebo. Gut barrier integrity markers were up\u2010regulated in mice receiving <jats:italic>B. pseudocatenulatum <\/jats:italic><jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content>7765 and quantitatively correlated with intestinal gene copy numbers of the bifidobacterial strain. Gene expression levels of several anti\u2010inflammatory mediators were also increased in mice receiving <jats:italic>B. pseudocatenulatum <\/jats:italic><jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content>7765 compared with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral administration of <jats:italic>B. pseudocatenulatum <\/jats:italic><jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content>7765 is associated with improved gut barrier integrity and shows a beneficial effect against induced bacterial antigen translocation in the <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>\u2010model of cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12380","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T20:44:07Z","timestamp":1383684247000},"page":"850-858","source":"Crossref","is-referenced-by-count":41,"title":["Protective effect of 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