{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:42:09Z","timestamp":1791276129625,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T00:00:00Z","timestamp":1387756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The goal of chronic hepatitis B (<jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>) treatment is to achieve seroclearance of HBsAg. Nucleos(t)ide analogues (<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>s) are one of the first\u2010line treatments for <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>s produce a potent suppression of viral replication but are associated with a low rate of HBsAg seroclearance and a high risk of virological relapse after discontinuation. Because of these reasons, long\u2010term treatment is needed. They are well\u2010tolerated oral drugs, and it seems they do not produce important side\u2010effects in long\u2010term administration. The duration of <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content> treatment remains unclear, nevertheless, in some patients <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>s can be stopped with a low rate of relapse. HBeAg\u2010positive patients could discontinue <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content> therapy if they achieved HBeAg seroclearance and maintain undetectable <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content>. For HBeAg\u2010negative patients, to stop <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content> treatment is not recommended. In addition to other factors, serum <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg titres during treatment have recently been proposed to guide <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010based therapy duration in selected patients. All patients could be stopped from taking treatment if they achieve HBsAg loss.<\/jats:p>","DOI":"10.1111\/liv.12398","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T07:49:39Z","timestamp":1387784979000},"page":"146-153","source":"Crossref","is-referenced-by-count":19,"title":["New therapeutic perspectives in <scp>HBV<\/scp>: when to stop <scp>NA<\/scp>s"],"prefix":"10.1111","volume":"34","author":[{"given":"Cristina","family":"P\u00e9rez\u2010Cameo","sequence":"first","affiliation":[{"name":"Liver Unit Department of Internal Medicine Hospital Universitari Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f2nica","family":"Pons","sequence":"additional","affiliation":[{"name":"Liver Unit Department of Internal Medicine Hospital Universitari Vall d'Hebron Barcelona 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