{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:28:28Z","timestamp":1753885708413},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection in haemodialysis (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) patients is still a matter of investigation. The aim of this study was to determine the histology of chronic hepatitis C (<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients within the context of a comparative analysis including non\u2010uraemic patients with <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>. The relative importance of virological, demographic and clinical parameters on disease manifestation was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010one consecutive liver biopsies from <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients and 326 from non\u2010uraemic patients with chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection were comparatively evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Haemodialysis patients with <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content> were older than control subjects (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.031), showing a similar <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype distribution (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.328) and lower viral load (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients was significantly milder according to stage (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.033), grade and its parameters (periportal activity, portal inflammation and lobular activity) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The frequency of lymphoid aggregates (10.2% vs 50%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), bile duct lesions (1.7% vs 22.1%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and extent of steatosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.022) in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> group was significantly reduced. Multivariate analysis showed that non\u2010uraemic patients had 2.3\u00a0times higher risk of developing steatosis independently of genotype distribution and age. In <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> group, genotype 3, longer <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> duration and age at infection were significantly associated with steatosis, while older age at infection correlated with advanced fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic hepatitis C in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients is usually very mild, losing its diagnostic histological features while patient's age and age at infection retain their prognostic significance. The weak inflammatory response, probably because of immunocompromised status and low viral load, may present a beneficial factor in the natural course of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12413","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T18:48:02Z","timestamp":1385405282000},"source":"Crossref","is-referenced-by-count":3,"title":["Histological features of chronic hepatitis C in haemodialysis patients"],"prefix":"10.1111","volume":"34","author":[{"given":"Stratigoula","family":"Sakellariou","sequence":"first","affiliation":[{"name":"First Department of Pathology Medical School University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John N.","family":"Boletis","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation Unit Medical School University of Athens, Laiko General Hospital Athens 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