{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:49:32Z","timestamp":1782175772892,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,12]],"date-time":"2014-01-12T00:00:00Z","timestamp":1389484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Triggers and exacerbants of cirrhotic cardiomyopathy (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) are poorly understood, limiting treatment options in patients with chronic liver diseases. Liver transplantation alone reverses some features of <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>, but the physiology behind this effect has never been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to determine whether reversal of liver injury and fibrosis in mouse affects cardiac parameters. The second aim was to determine whether cardiomyopathy can be induced by specifically increasing systemic bile acid (<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>6\u20138\u00a0week old male C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>6J mice were fed either chow (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) or 3,5\u2010diethoxycarbonyl\u20101,4\u2010dihydroxychollidine (<jats:styled-content style=\"fixed-case\">DDC<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) for 3\u00a0weeks. At the end of 3\u00a0weeks, half the mice in the <jats:styled-content style=\"fixed-case\">DDC<\/jats:styled-content> fed group were randomized to chow (the reversed [<jats:styled-content style=\"fixed-case\">REV<\/jats:styled-content>] group). Serial <jats:styled-content style=\"fixed-case\">ECHO<\/jats:styled-content>s and electrocardiographic analysis was conducted weekly for 6\u00a0weeks followed by liver tissue and serum studies. Hearts were analysed for key components of function and cell signalling. Cardiac physiological and molecular parameters were similarly analysed in Abcb11<jats:sup>\u2212\/\u2212<\/jats:sup> mice (<jats:italic>n<\/jats:italic>\u00a0=\u00a05\/grp) fed 0.5% cholic acid supplemented diet for 1\u00a0week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mice in the <jats:styled-content style=\"fixed-case\">REV<\/jats:styled-content> group showed normalization of biochemical markers of liver injury with resolution of electrocardiographic and <jats:styled-content style=\"fixed-case\">ECHO<\/jats:styled-content> aberrations. Catecholamine resistance seen in <jats:styled-content style=\"fixed-case\">DDC<\/jats:styled-content> group resolved in the <jats:styled-content style=\"fixed-case\">REV<\/jats:styled-content> group. Cardiac recovery was accompanied by normalization of cardiac troponin\u2010T2 as well as resolution of cardiac stress response at <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> level. Cardiovascular physiological and molecular parameters correlated with degree of cholanemia. Cardiomyopathy was reproduced in cholanemic <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> fed Abcb11<jats:sup>\u2212\/\u2212<\/jats:sup> mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cardiomyopathy resolves with resolution of liver injury, is associated with cholanaemia, and can be induced by <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> feeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12438","type":"journal-article","created":{"date-parts":[[2013,12,14]],"date-time":"2013-12-14T09:04:47Z","timestamp":1387011887000},"page":"1464-1477","source":"Crossref","is-referenced-by-count":23,"title":["Cardiomyopathy reverses with recovery of liver injury, cholestasis and cholanemia in mouse model of biliary fibrosis"],"prefix":"10.1111","volume":"35","author":[{"given":"Moreshwar S.","family":"Desai","sequence":"first","affiliation":[{"name":"Section of Pediatric Critical Care Baylor College of Medicine Houston TX 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