{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:17:05Z","timestamp":1770977825654,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Poor initial graft function was recently newly defined as early allograft dysfunction (<jats:styled-content style=\"fixed-case\">EAD<\/jats:styled-content>) [Olthoff KM, Kulik L, Samstein B, <jats:italic>et\u00a0al<\/jats:italic>. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. <jats:italic>Liver Transpl<\/jats:italic> 2010; 16: 943]. Aim of this analysis was to evaluate predictive donor information for development of <jats:styled-content style=\"fixed-case\">EAD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six hundred and seventy\u2010eight consecutive adult patients (mean age 51.6\u00a0years; 60.3% men) who received a primary liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) (09\/2003\u201312\/2011) were included. Standard donor data were correlated with <jats:styled-content style=\"fixed-case\">EAD<\/jats:styled-content> and outcome by univariable\/multivariable logistic regression and Cox proportional hazards to identify prognostic donor factors after adjustment for recipient confounders. Estimates of relevant factors were utilized for construction of a new continuous risk index to develop <jats:styled-content style=\"fixed-case\">EAD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>38.7% patients developed EAD. 30\u2010day survival of grafts with and without EAD was 59.8% and 89.7% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). 30\u2010day survival of patients with and without EAD was 68.5% and 93.1% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) respectively. Donor body mass index (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0112), <jats:styled-content style=\"fixed-case\">gGT<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0471), macrosteatosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0006) and cold ischaemia time (CIT) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0031) were predictors of EAD. Internal cross validation showed a high predictive value (<jats:italic>c<\/jats:italic>\u2010index\u00a0=\u00a00.622).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early allograft dysfunction correlates with early results of <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> and can be predicted by donor data only. The newly introduced risk index potentially optimizes individual decisions to accept\/decline high risk organs. Outcome of these organs might be improved by shortening <jats:styled-content style=\"fixed-case\">CIT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12443","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T15:27:38Z","timestamp":1387380458000},"page":"156-163","source":"Crossref","is-referenced-by-count":83,"title":["Donor information based prediction of early allograft dysfunction and outcome in liver transplantation"],"prefix":"10.1111","volume":"35","author":[{"given":"Dieter P.","family":"Hoyer","sequence":"first","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery University Hospital Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery University Hospital Essen 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