{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:49:29Z","timestamp":1789602569864,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Various modalities have been employed effectively according to the tumour recurrence status in patients with hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) undergoing hepatectomy. Therefore, their overall prognosis depends largely on the pattern of recurrence\/treatment. We investigated the patterns of recurrence and prognosis in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients, especially in relation to the hepatitis virus infection status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population comprised 244 patients with <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> undergoing hepatectomy. Curative treatments, including repeated hepatectomies, were performed for recurrences, whenever possible. Detailed information on recurrences was collected until the recurrences exceeded Milan criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 5\u2010year disease\u2010free survival, survival within the Milan criteria and overall survival were 38.4%, 56.3% and 74.5% respectively. In the comparison between patients with hepatitis C and B virus\u2010related <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>:<jats:italic> n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>122; and <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>:<jats:italic> n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>45 respectively), the former showed lower disease\u2010free (30.2% vs. 40.7% at 5\u00a0years, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.061) and overall (65.7% vs. 89.7% at 5\u00a0years, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.011) survivals; they also showed a higher incidence of multinodular (\u22654) intrahepatic recurrences (19.4% vs. 5.3% at 3\u00a0years, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.010). However, the incidences of recurrences exceeding the Milan criteria because of other components were comparable. Patients with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> showed a higher incidence of intrahepatic recurrences characterized by multiple lesions and the difference became increasingly more pronounced with time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> were associated with a higher carcinogenesis in the background liver than those with <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>, and this difference was aggravated with time after hepatic resection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12447","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T15:28:45Z","timestamp":1387380525000},"page":"802-813","source":"Crossref","is-referenced-by-count":25,"title":["Postoperative recurrence pattern and prognosis of patients with hepatocellular carcinoma, with particular reference to the hepatitis viral infection status"],"prefix":"10.1111","volume":"34","author":[{"given":"Shigetoshi","family":"Naito","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary\u2010Pancreatic Surgery Juntendo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary\u2010Pancreatic Surgery Juntendo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Tukada","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary\u2010Pancreatic Surgery Juntendo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Graduate School of Medicine University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary\u2010Pancreatic Surgery Juntendo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Sugo","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary\u2010Pancreatic Surgery Juntendo University School of Medicine Tokyo 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