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The impact of large volume paracentesis (<jats:styled-content style=\"fixed-case\">LVP<\/jats:styled-content>) on the 24\u2010h blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) profile is unknown, and the relationship to Na<jats:sup>+<\/jats:sup>\u2010retentive and pro\u2010inflammatory cytokines also remains unknown. The aims of this study were to (i) define the effects of <jats:styled-content style=\"fixed-case\">LVP<\/jats:styled-content> with albumin administration on 24\u2010h <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> profiles, and (ii) relate changes in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> over time to changes in Na<jats:sup>+<\/jats:sup>\u2010retentive hormones, clinical factors and inflammatory cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients undergoing <jats:styled-content style=\"fixed-case\">LVP<\/jats:styled-content> had 24\u2010h ambulatory <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> monitoring performed pre\u2010 and post\u2010paracentesis. Markers of the innate immune system, bacterial translocation and Na<jats:sup>+<\/jats:sup>\u2010retentive hormones were drawn pre\u2010 and post\u2010<jats:styled-content style=\"fixed-case\">LVP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean arterial pressure (<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>) dropped in nine of the 10 patients in the 24\u00a0h following a paracentesis compared to 24\u00a0h preceding the procedure (mean drop of 5.5\u00a0mmHg, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005). A mixed effects model was used to define time\u2010covariate interactions in predicting changes in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> profile. Monocyte chemotactic protein\u20101 (<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>1) was associated with \u0394systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (\u03b2\u00a0=\u00a0\u22120.011, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), \u0394diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (\u03b2\u00a0=\u00a0\u22120.012, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and \u0394<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> (\u03b2\u00a0=\u00a0\u22120.012, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Plasma renin activity was also significantly associated with \u0394systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (\u03b2\u00a0=\u00a0\u22120.21, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Renal function was also significantly reduced following <jats:styled-content style=\"fixed-case\">LVP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systolic, diastolic and MAP decreased over 24\u00a0h after <jats:styled-content style=\"fixed-case\">LVP<\/jats:styled-content> compared to the 24\u00a0h pre\u2010<jats:styled-content style=\"fixed-case\">LVP<\/jats:styled-content>. This drop is related to increases in <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 after <jats:styled-content style=\"fixed-case\">LVP<\/jats:styled-content>. Increased <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101, a marker of monocyte activation, was strongly related to changes in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12450","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T08:40:39Z","timestamp":1387874439000},"page":"1001-1007","source":"Crossref","is-referenced-by-count":8,"title":["Post\u2010paracentesis circulatory derangements are related to monocyte activation"],"prefix":"10.1111","volume":"34","author":[{"given":"Daniel E.","family":"Carl","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine School of Medicine Virginia Commonwealth University (VCU) Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddharta","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine School of Medicine Virginia Commonwealth University (VCU) Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Carolina Medical Center Charlotte NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd W. 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